SIGNIFICANCE Low-frequency oscillations (LFOs) ranging from 0.01 to 0.15 Hz are common in functional imaging studies. Some of these LFOs are non-neuronal and are correlated with autonomic physiological processes. AIM We investigate the relationships between systemic low-frequency oscillations (sLFOs) measured at different peripheral sites during resting states in ischemic stroke patients. APPROACH Twenty-seven ischemic stroke patients (ages 44 to 90; 20 male and 7 female) were recruited for the study. During the experiments, fluctuations in oxyhemoglobin concentration were measured in the left and right toes, fingertips, and earlobes using a multichannel near-infrared spectroscopy instrument. We applied cross-correlation and frequency component analyses on the sLFO data. RESULTS The results showed that embolization broke the symmetry of the sLFO transmission and that the damage was not limited to the local area but spread throughout the body. Among six peripheral sites, the power spectrum width of the earlobes was significantly larger than that of the fingers and toes. This indicates that the earlobes may contain more physiological information. Finally, the results of fuzzy clustering verified that sLFOs can serve as perfusion biomarkers to differentiate stroke from healthy subjects. CONCLUSIONS The high correlation values and corresponding delays in sLFOs support the hypothesis that (1) the correlation characteristics of sLFOs in stroke patients are different from those of healthy subjects. These characteristics can reflect patient condition, to an extent. Embolization in ischemic stroke patients breaks the symmetry of the body's sLFO transmission, disrupting the balance of blood circulation. (2) sLFOs can be used as perfusion biomarkers to differentiate ischemic stroke patients from healthy subjects. Studying these signals can explicate the overall feedback/influence of pericentral interactions. Finally, peripheral sLFOs have been shown to be an effective and accurate tool for assessing peripheral blood circulation and vascular integrity in ischemic stroke patients.

中文翻译：

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使用 NIRS 评估的缺血性卒中患者外周血管生物标志物的不对称性。

意义 范围从 0.01 到 0.15 Hz 的低频振荡 (LFO) 在功能成像研究中很常见。其中一些 LFO 是非神经元的，与自主生理过程相关。目的我们调查缺血性卒中患者在静息状态下在不同外周部位测量的全身低频振荡 (sLFO) 之间的关系。方法 招募了 27 名缺血性中风患者（44 至 90 岁；20 名男性和 7 名女性）进行研究。在实验过程中，使用多通道近红外光谱仪测量了左右脚趾、指尖和耳垂的氧合血红蛋白浓度的波动。我们对 sLFO 数据应用了互相关和频率分量分析。结果 结果表明，栓塞破坏了 sLFO 传输的对称性，损害不仅限于局部区域，而是遍布全身。在六个周边部位中，耳垂的功率谱宽度明显大于手指和脚趾的功率谱宽度。这表明耳垂可能包含更多的生理信息。最后，模糊聚类的结果证实 sLFO 可以作为灌注生物标志物来区分中风和健康受试者。结论 sLFO 的高相关值和相应的延迟支持以下假设：(1) 中风患者 sLFO 的相关特征与健康受试者不同。这些特征可以在一定程度上反映患者的状况。缺血性中风患者的栓塞破坏了身体 sLFO 传输的对称性，破坏了血液循环的平衡。(2) sLFOs 可作为灌注生物标志物来区分缺血性中风患者和健康受试者。研究这些信号可以解释中央周围相互作用的整体反馈/影响。最后，外周 sLFO 已被证明是评估缺血性中风患者外周血循环和血管完整性的有效且准确的工具。