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Hypolipidemic and anti-inflammatory properties of phenolic rich Butia odorata fruit extract: potential involvement of paraoxonase activity.
Biomarkers ( IF 2.0 ) Pub Date : 2020-06-20 , DOI: 10.1080/1354750x.2020.1781261
Vanessa Plasse Ramos 1 , Pamela Gonçalves da Silva 1 , Pathise Souto Oliveira 1 , Natália Pontes Bona 1 , Mayara Sandrielly Pereira Soares 2 , Juliane de Souza Cardoso 1 , Jessica Fernanda Hoffmann 3 , Fábio Clasen Chaves 3 , Augusto Schneider 4 , Roselia Maria Spanevello 2 , Claiton Leoneti Lencina 1 , Francieli Moro Stefanello 1 , Rejane Giacomelli Tavares 1
Affiliation  

Aim: This study investigated the effects of polar Butia odorata fruit extract on metabolic, inflammatory, and oxidative stress parameters in rats submitted to a hyperlipidaemia condition induced by tyloxapol.

Methods: Animals were divided into 3 groups: saline, saline plus tyloxapol, and B. odorata extract plus tyloxapol. Animals were treated for 15 days with a saline solution or B. odorata fruit extract and after hyperlipidaemia was induced by tyloxapol.

Results: Treatment with B. odorata extract reduced serum triglyceride, total cholesterol, C-reactive protein, and adenosine deaminase and butyrylcholinesterase activities when compared to the tyloxapol group. HDL-cholesterol and paraoxonase 1 activity were higher in B. odorata extract treated animals when compared to tyloxapol-treated animals. No differences were observed in hepatic oxidative stress parameters. Phenolic compounds present in B. odorata fruit extract were identified and quantified by LC-MS/MS.

Conclusion: These findings indicated that phenolic rich B. odorata extract has hypolipidemic and anti-inflammatory effects in hyperlipidemic rats.



中文翻译:

富含酚的Butia odorata水果提取物的降脂和抗炎特性:对氧磷酶活性的潜在参与。

目的:本研究探讨极地的影响,布迪椰子飞机草在提交给泰洛沙引起的高脂血症大鼠条件代谢,炎症和氧化应激参数果提取物。

方法:将动物分为三组:生理盐水,生理盐水加泰洛沙泊,香菇芽孢杆菌提取物加泰洛沙泊。用盐溶液或香柠檬芽孢杆菌果实提取物处理动物15天,然后由泰洛沙泊诱导高脂血症。

结果:与泰乐沙泊组相比,用香菇芽孢杆菌提取物治疗可降低血清甘油三酸酯,总胆固醇,C反应蛋白以及腺苷脱氨酶和丁酰胆碱酯酶的活性。高密度脂蛋白胆固醇和对氧磷酶1活性较高B.飞机草相比,泰洛沙治疗的动物时,提取处理的动物。肝氧化应激参数没有观察到差异。通过LC-MS / MS鉴定并定量了香菇果实提取物中存在的酚类化合物。

结论:这些发现表明,富含酚的香茅提取物对高脂血症大鼠具有降血脂和抗炎作用。

更新日期:2020-06-29
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