Myeloid-derived suppressor cells (MDSCs) are notable contributors to the immunosuppressive tumor microenvironment (TME) and are closely associated with tumor progression; in addition, MDSCs are present in most patients with cancer. However, the molecular mechanisms that regulate MDSCs in the etiopathogenesis of human tumor immunity remain unclear. The secreted alarmin high mobility group box 1 (HMGB1) is a proinflammatory factor and inducer of many inflammatory molecules during MDSC development. In this review, we detail the currently reported characteristics of MDSCs in tumor immune escape and the regulatory role of secreted HMGB1 in MDSC differentiation, proliferation, activity and survival. Notably, different posttranslational modifications of HMGB1 may have various effects on MDSCs, and these effects need further identification. Moreover, exosome-derived HMGB1 is speculated to exert a regulatory effect on MDSCs, but no report has confirmed this hypothesis. Therefore, the effects of HMGB1 on MDSCs need more research attention, and additional investigations should be conducted.

中文翻译：

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HMGB1在调节肿瘤微环境中髓样来源的抑制细胞中的作用。

骨髓来源的抑制细胞（MDSCs）是免疫抑制肿瘤微环境（TME）的重要贡献者，并且与肿瘤进展密切相关。另外，大多数癌症患者中都存在MDSC。然而，尚不清楚在人类肿瘤免疫的发病机理中调节MDSC的分子机制。分泌的警报蛋白高迁移率族盒1（HMGB1）是MDSC发育过程中的促炎因子和许多炎症分子的诱导剂。在这篇综述中，我们详细介绍了当前报道的MDSCs在肿瘤免疫逃逸中的特征，以及分泌的HMGB1在MDSC分化，增殖，活性和存活中的调控作用。值得注意的是，HMGB1的不同翻译后修饰可能会对MDSCs产生各种影响，这些作用需要进一步鉴定。此外，推测外泌体衍生的HMGB1对MDSC发挥调节作用，但尚无报道证实这一假设。因此，HMGB1对MDSCs的作用需要更多的研究关注，应进行更多的研究。