Dragendorff's reagent has low sensitivity and non‐specificity for some alkaloids. A new alkaloid derivatisation reagent has been developed and optimised by using a Box–Behnken design method. This new reagent is applicable for structurally diverse natural alkaloids, and is proposed as a universal alkaloid staining reagent.

中文翻译：

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新开发的通过响应面法优化的通用衍生化试剂辅助TLC-MS鉴定益母草和益母草中的生物碱

Dragendorff的试剂对某些生物碱具有较低的灵敏度和非特异性。通过使用Box–Behnken设计方法，已开发并优化了一种新的生物碱衍生化试剂。该新试剂可用于结构多样的天然生物碱，并被提议作为通用生物碱染色试剂。