Metastatic cancer is caused by hyperactivated lysosomes. Such activation causes a fungus, Aspergillus fumigatus, to permanently activate the AKT gene network that controls the lysosome through positive feedback loops. Targeting such a network by the redox balance change, and with an antifungal medication eliminates the metastatic phenotype, the complexity and robustness of the cancer. This principal mechanism of gene targeting, which suppressed metastasis of unknown origin, was observed clinically.

中文翻译：

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转移性癌症中的溶酶体 AKT 靶向。

转移性癌症是由过度活化的溶酶体引起的。这种激活导致真菌烟曲霉永久激活通过正反馈回路控制溶酶体的 AKT 基因网络。通过氧化还原平衡的变化靶向这种网络，并使用抗真菌药物消除转移表型、癌症的复杂性和稳健性。这种抑制未知来源转移的基因靶向的主要机制在临床上得到了观察。