Cytoskeletal regulation of dendritic cells: An intricate balance between migration and presentation for tumor therapy.,Journal of Leukocyte Biology

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Cytoskeletal regulation of dendritic cells: An intricate balance between migration and presentation for tumor therapy.
Journal of Leukocyte Biology ( IF 3.6 ) Pub Date : 2020-06-18 , DOI: 10.1002/jlb.1mr0520-014rr
Mariana M S Oliveira ₁ , Lisa S Westerberg ₁

Affiliation

Dendritic cells (DCs) are the main players in many approaches for cancer therapy. The idea with DC tumor therapy is to promote activation of tumor infiltrating cytotoxic T cells that kill tumor cells. This requires that DCs take up tumor Ag and present peptides on MHC class I molecules in a process called cross‐presentation. For this process to be efficient, DCs have to migrate to the tumor draining lymph node and there activate the machinery for cross‐presentation. In this review, we will discuss recent progress in understanding the role of actin regulators for control of DC migration and Ag presentation. The potential to target actin regulators for better DC‐based tumor therapy will also be discussed.

中文翻译：

树突状细胞的细胞骨架调节：肿瘤治疗在迁移和表现之间的复杂平衡。

树突状细胞（DC）是许多癌症治疗方法的主要参与者。DC肿瘤疗法的想法是促进杀死肿瘤细胞的浸润性细胞毒性T细胞的活化。这要求DC吸收肿瘤抗原，并以称为交叉呈递的过程将肽呈递给MHC I类分子。为了使该过程有效，DC必须迁移到引流肿瘤的淋巴结，并在那里激活交叉展示的机制。在这篇综述中，我们将讨论了解肌动蛋白调节剂在控制DC迁移和Ag呈递中的作用的最新进展。还将讨论针对肌动蛋白调节剂靶向更好的基于DC的肿瘤治疗的潜力。

更新日期：2020-06-18

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