Notch signaling at the crossroads of innate and adaptive immunity,Journal of Leukocyte Biology

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Notch signaling at the crossroads of innate and adaptive immunity
Journal of Leukocyte Biology ( IF 3.6 ) Pub Date : 2020-06-18 , DOI: 10.1002/jlb.1ri0520-138r
Ashley Vanderbeck _{1,

2} , Ivan Maillard _{1,

3,

4}

Affiliation

Notch signaling is an evolutionarily conserved cell‐to‐cell signaling pathway that regulates cellular differentiation and function across multiple tissue types and developmental stages. In this review, we discuss our current understanding of Notch signaling in mammalian innate and adaptive immunity. The importance of Notch signaling is pervasive throughout the immune system, as it elicits lineage and context‐dependent effects in a wide repertoire of cells. Although regulation of binary cell fate decisions encompasses many of the functions first ascribed to Notch in the immune system, recent advances in the field have refined and expanded our view of the Notch pathway beyond this initial concept. From establishing T cell identity in the thymus to regulating mature T cell function in the periphery, the Notch pathway is an essential, recurring signal for the T cell lineage. Among B cells, Notch signaling is required for the development and maintenance of marginal zone B cells in the spleen. Emerging roles for Notch signaling in innate and innate‐like lineages such as classical dendritic cells and innate lymphoid cells are likewise coming into view. Lastly, we speculate on the molecular underpinnings that shape the activity and versatility of the Notch pathway.

中文翻译：

固有信号和适应性免疫的十字路口上的Notch信号

Notch信号传导是一种进化上保守的细胞间信号传导途径，可调节多种组织类型和发育阶段的细胞分化和功能。在这篇综述中，我们讨论了我们目前对哺乳动物先天性和适应性免疫中的Notch信号的理解。Notch信号的重要性在整个免疫系统中无处不在，因为它在广泛的细胞库中引起谱系和背景依赖效应。尽管对二元细胞命运决定的调节涵盖了最初归因于免疫系统中Notch的许多功能，但是该领域的最新进展已经超越了这个最初的概念，进一步完善和扩展了我们对Notch途径的看法。从在胸腺中建立T细胞身份到调节周围的成熟T细胞功能，Notch通路都是必不可少的，T细胞谱系的重复信号。在B细胞中，Notch信号是脾脏边缘B区细胞发育和维持所必需的。在先天和先天性谱系中，例如经典树突状细胞和先天性淋巴样细胞中，Notch信号的新兴作用也同样受到关注。最后，我们推测了影响Notch通路活性和多功能性的分子基础。

更新日期：2020-06-18

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