Glioma is known as one of the most common primary intracranial tumors accounting for four-fifths of malignant brain tumors. There are several biological pathways that play a synergistic, pathophysiological role in glioma, including apoptosis, autophagy, oxidative stress, and cell cycle arrest. According to previous rese arches, the drugs used in the treatment of glioma have been associated with significant limitations. Therefore, improved and/or new therapeutic platforms are required. In this regard, multiple flavonoids and alkaloids have been extensively studied in the treatment of glioma. Berberine is a protoberberine alkaloid with wide range of pharmacological activities, applicable to various pathological conditions. Few studies have reported beneficial roles of berberine in glioma. Berberine exerts its pharmacological functions in glioma by controlling different molecular and cellular pathways. We reviewed the existing knowledge supporting the use of berberine in the treatment of glioma and its effects on molecular and cellular mechanisms.

胶质瘤被认为是最常见的原发性颅内肿瘤之一，占恶性脑肿瘤的五分之四。有多种生物学途径在神经胶质瘤中发挥协同病理生理作用，包括细胞凋亡、自噬、氧化应激和细胞周期停滞。根据之前的研究，用于治疗神经胶质瘤的药物存在很大的局限性。因此，需要改进的和/或新的治疗平台。在这方面，多种类黄酮和生物碱在神经胶质瘤的治疗中得到了广泛的研究。小檗碱是一种原小檗碱生物碱，具有广泛的药理活性，适用于多种病理情况。很少有研究报道小檗碱对神经胶质瘤的有益作用。小檗碱通过控制不同的分子和细胞途径在神经胶质瘤中发挥其药理功能。我们回顾了支持使用小檗碱治疗神经胶质瘤及其对分子和细胞机制的影响的现有知识。