Nowadays, scientists focus on the development of tissue-specific and personalized bio-ink that can be used in 3D bioprinting technologies. Platelet-rich plasma (PRP) is a person-specific source that is used as a therapeutic adjunct for the treatment of cartilage damage because it offers a cocktail of growth factors that are necessary for wound healing and tissue regeneration. However, PRP treatments in the clinic are not satisfactory and require upgrading, especially the point of maintaining bioactivity. In this study, we presented PRP as a photo-activated and photo-crosslinkable bio-ink in terms of tissue-specific structures for the first time. We achieved long-term and constant rate growth factor release and bioactivity protection of PRP with satisfactory mechanical characteristics. Photo-crosslinked PRP hydrogel was enabled by the addition of microwave-induced methacrylated gelatin (Gel-MA), which is connected to platelets in PRP via integrin receptors in its structure and ch...

中文翻译：

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基于光激活富血小板血浆 (PRP) 的患者特异性生物墨水，用于软骨组织工程。

如今，科学家们专注于开发可用于 3D 生物打印技术的组织特异性和个性化生物墨水。富含血小板血浆 (PRP) 是一种针对个人的来源，可用作治疗软骨损伤的治疗辅助剂，因为它提供了伤口愈合和组织再生所需的生长因子混合物。然而，临床上的PRP治疗效果并不理想，需要升级，特别是在维持生物活性这一点上。在这项研究中，我们首次将 PRP 作为一种组织特异性结构的光激活和光交联生物墨水。我们实现了PRP的长期、恒定速率的生长因子释放和生物活性保护，并具有令人满意的机械特性。