An unusual group A rotavirus (RVA) strain (RVA/Human-tc/EGY/AS997/2012/G9[14]) was isolated for the first time in a faecal sample from a 6-month-old child who was hospitalized for treatment of acute gastroenteritis in Egypt in 2012. Whole-genome analysis showed that the strain AS997 had a unique genotype constellation: G9-P[14]-I2-R2-C2-M2-A11-N2-T1-E2-H1. Phylogenetic analysis indicated that the strain AS997 had the consensus P[14] genotype constellation with the G9, T1 and H1 reassortment. This suggests either a mixed gene configuration originated from a human Wa-like strain and a P[14]-containing animal virus, or that this P[14] could have been acquired via reassortment of human strains only. The study shows the possible roles of interspecies transmission and multiple reassortment events leading to the generation of novel rotavirus genotypes and underlines the importance of whole-genome characterization of rotavirus strains in surveillance studies.

中文翻译：

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埃及一位腹泻儿童的G9P [14]轮状病毒株的首次分离和全基因组鉴定。

首次从一名住院治疗的6个月大儿童的粪便样本中分离出一种不寻常的A型轮状病毒（RVA）株（RVA / Human-tc / EGY / AS997 / 2012 / G9 [14]）。全基因组分析显示，AS997菌株具有独特的基因型星座：G9-P [14] -I2-R2-C2-M2-A11-N2-T1-E2-H1。系统发育分析表明，菌株AS997具有G9，T1和H1重排的共有P [14]基因型构象。这表明，要么是源自人类Wa型毒株和含有P [14]的动物病毒的混合基因构型，要么可能是仅通过人类毒株的重新分类而获得的P [14]。