Lethality due to dengue infection is a global threat. Nearly 400 million people are affected every year, which approximately costs 500 million dollars for surveillance and vector control itself. Many investigations on the structure-function relationship of proteins expressed by the dengue virus are being made for more than a decade and had come up with many reports on small molecule drug discovery. In this review, we present a detailed note on viral proteins and their functions as well as the inhibitors discovered/designed so far using experimental and computational methods. Further, the phytoconstituents from medicinal plants, specifically the extract of the papaya leaves, neem and bael, which combat dengue infection via dengue protease, helicase, methyl transferase and polymerase are summarized.

中文翻译：

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确定与登革热有关的靶标的潜在抑制剂。

登革热感染致死率是全球性威胁。每年有近4亿人受到影响，监视和病媒控制本身的成本约为5亿美元。登革热病毒表达的蛋白质的结构-功能关系的许多研究已经进行了十多年，并提出了许多有关小分子药物发现的报告。在这篇综述中，我们提供了有关病毒蛋白及其功能以及迄今为止使用实验和计算方法发现/设计的抑制剂的详细说明。此外，归纳了来自药用植物的植物成分，特别是番木瓜叶，印em和鲍尔的提取物，它们通过登革热蛋白酶，解旋酶，甲基转移酶和聚合酶来抵抗登革热感染。