Background: Stroke is one of the causes of death and disability globally. Brain attack is because of the acute presentation of stroke, which highlights the requirement for decisive action to treat it.

Objective: The mechanism and in-vivo experimental models of stroke with various neuroprotective agents are highlighted in this review.

Method: The damaging mechanisms may proceed by rapid, nonspecific cell lysis (necrosis) or by the active form of cell death (apoptosis or necroptosis), depending upon the duration and severity and of the ischemic insult.

Results: Identification of injury mediators and pathways in a variety of experimental animal models of global cerebral ischemia has directed to explore the target-specific cytoprotective strategies, which are critical to clinical brain injury outcomes.

Conclusion: The injury mechanism, available encouraging medicaments thereof, and outcomes of natural and modern medicines for ischemia have been summarized. In spite of available therapeutic agents (thrombolytics, calcium channel blockers, NMDA receptor antagonists and antioxidants), there is a need for an ideal drug for strokes.

背景：中风是全球范围内死亡和残疾的原因之一。脑部发作的原因是中风的急性发作，这突显了需要采取果断行动来治疗中风。

目的：本文综述了多种神经保护剂对中风的作用机制和体内实验模型。

方法：取决于持续时间，严重程度和缺血性损伤，破坏机制可能通过快速的非特异性细胞溶解（坏死）或细胞死亡的活跃形式（凋亡或坏死性坏死）来进行。

结果：在各种全球性脑缺血的实验动物模型中鉴定损伤介质和途径，旨在探索靶标特异性的细胞保护策略，这对临床脑损伤的结果至关重要。

结论：总结了损伤机制，可用的鼓励药物以及天然和现代药物对缺血的预后。尽管有可用的治疗剂（溶栓剂，钙通道阻滞剂，NMDA受体拮抗剂和抗氧化剂），仍需要一种理想的中风药物。