Long non-coding RNAs (lncRNAs) are a diverse class of longer than 200 nucleotides RNA transcripts that have limited protein coding capacity. LncRNAs display diverse cellular functions and widely participate in both physiological and pathophysiological processes. Aberrant expressions of lncRNAs are correlated with tumor progression, providing sound rationale for their targeting as attractive anti-tumor therapeutic strategies. Emerging evidences support that lncRNAs participate in tumor-stroma crosstalk and stimulate a distinctive and suitable tumor microenvironment (TME). The TME comprises several stromal cells such as cancer stem cells (CSCs), cancer-associated endothelial cells (CAEs), cancer-associated fibroblasts (CAFs) and infiltrated immune cells, all of which are involved in the complicated crosstalk with tumor cells to affect tumor progression. In this review, we summarize the essential properties and functional roles of known lncRNAs in related to the TME to validate lncRNAs as potential biomarkers and promising anti-cancer targets.

中文翻译：

---

长链非编码 RNA 在肿瘤微环境中的新兴作用。

长链非编码 RNA (lncRNAs) 是一类多于 200 个核苷酸的 RNA 转录本，其蛋白质编码能力有限。LncRNA 显示出多种细胞功能，并广泛参与生理和病理生理过程。lncRNA 的异常表达与肿瘤进展相关，为它们作为有吸引力的抗肿瘤治疗策略的靶向提供了合理的理由。新出现的证据支持 lncRNA 参与肿瘤-基质串扰并刺激独特且合适的肿瘤微环境 (TME)。TME 包括几种基质细胞，如癌症干细胞 (CSC)、癌症相关内皮细胞 (CAE)、癌症相关成纤维细胞 (CAF) 和浸润免疫细胞，所有这些都涉及与肿瘤细胞的复杂串扰，从而影响肿瘤的进展。在这篇综述中，我们总结了与 TME 相关的已知 lncRNA 的基本特性和功能作用，以验证 lncRNA 作为潜在的生物标志物和有希望的抗癌靶点。