Whilst detrimental effects of repeated sub-concussive impacts on neurophysiological and behavioral function are increasingly reported, the underlying mechanisms are largely unknown. Here, we report that repeated sub-concussion with a light weight drop (25 g) in wild-type PVG rats for 2 weeks does not induce detectable neuromotor dysfunction assessed by beamwalk and rotarod tests. However, after 12 weeks of repeated sub-concussion, the rats exhibited moderate neuromotor dysfunction. This is the first study to demonstrate development of neuromotor dysfunction following multiple long-term sub-concussive impacts in rats. The outcomes may offer significant opportunity for future studies to understand the mechanisms of sub-concussion-induced neuropsychological changes.

中文翻译：

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反复的长期亚脑震荡诱发大鼠运动功能障碍：潜在的啮齿动物模型。

虽然越来越多地报告了反复的脑震荡对神经生理和行为功能的有害影响，但其潜在机制在很大程度上尚不清楚。在这里，我们报告称，在野生型PVG大鼠中轻度下降（25 g）反复亚震荡2周，并没有通过束流步法和旋转仪测试评估可检测到的神经运动功能障碍。然而，在反复进行脑震荡12周后，大鼠表现出中度神经运动功能障碍。这是第一个证明在大鼠中多次长期亚脑震荡后神经运动功能障碍发展的研究。结果可能为未来的研究提供重要的机会，以了解脑震荡诱发的神经心理变化的机制。