Background

Atopic dermatitis (AD) is associated with heterogeneous triggers of itch, which may affect AD course and severity.

Objective

To characterize the triggers of itch in adult AD.

Methods

This was a prospective dermatology practice–based study using questionnaires and evaluation by a dermatologist (n = 587). Thirteen itch triggers were assessed using the patient-reported outcomes measurement information system Itch-Triggers.

Results

Overall, 381 (64.9%) patients reported greater than or equal to 1 itch trigger in the past week and 212 (36.1%) reported greater than or equal to 3 itch triggers. The most commonly reported triggers were stress (35.4%), sweat (30.5%), weather change (24.7%), dry air (24.4%), and heat (24.0%). In multivariable Poisson regression models, the number of itch triggers was associated with more severe patient-reported global AD severity, Numeric Rating Scale worst itch, Patient-Oriented Eczema Measure, Scoring Atopic Dermatitis sleep, Numeric Rating Scale skin pain, Eczema Area and Severity Index, and objective Scoring Atopic Dermatitis. The seasonality of AD was associated with distinct itch triggers. In multivariable logistic regression models, the number of itch triggers was associated with less than or equal to 3 months of AD remission during the year, greater than or equal to 2 AD flares, and AD being worse during some seasons. Four patterns of itch triggers were identified using latent class analysis, each associated with different clinical characteristics.

Conclusion

Itch triggers are common and affect the course of AD. Itch triggers are an important end point to assess in patients with AD.

中文翻译：

---

成人瘙痒触发因素与特应性皮炎的严重程度和病程相关。

背景

特应性皮炎（AD）与瘙痒的异质性诱因有关，这可能会影响AD病程和严重程度。

目的

表征成人AD中瘙痒的诱因。

方法

这是一项基于前瞻性皮肤病实践的研究，使用问卷和皮肤科医生进行评估（n = 587）。使用患者报告的结果测量信息系统Itch-Triggers评估了13种瘙痒触发因素。

结果

总体而言，在过去一周中，有381（64.9％）位患者报告了大于或等于1个瘙痒触发，而有212位患者（36.1％）报告了大于或等于3个痒触发。最常见的诱因是压力（35.4％），汗水（30.5％），天气变化（24.7％），干燥空气（24.4％）和热量（24.0％）。在多变量Poisson回归模型中，瘙痒触发的次数与患者报告的更严重的总体AD严重程度，数字评分等级最严重的瘙痒，以人为本的湿疹测量，特应性皮炎的睡眠评分，数字评分等级有关的皮肤疼痛，湿疹面积和严重程度相关指标和客观计分的特应性皮炎。AD的季节性与明显的瘙痒触发有关。在多变量Logistic回归模型中，一年中，瘙痒触发的次数与少于或等于3个月的AD缓解，大于或等于2次AD爆发有关，并且在某些季节中AD恶化。使用潜在类别分析确定了四种瘙痒触发模式，每种模式均具有不同的临床特征。

结论

瘙痒触发很常见，会影响AD病程。瘙痒触发因素是评估AD患者的重要终点。