INTRODUCTION We provide here an overview on current worldwide epidemiology of pancreatic malignancies, obtained from Global Health Data Exchange (GHDx) and World Health Organization (WHO) repositories. MATERIAL AND METHODS Electronic searches for collecting information on pancreatic cancer epidemiology were performed in official repositories of GHDx and WHO, and retrieved data were then analyzed. RESULTS Overall, 447 665 new cases of pancreatic cancer were recorded around the world in 2017 (58.6 per million), with global prevalence of 49.8 per million and 441 083 deaths (57.7 per million). Incidence, prevalence and mortality increased by 55%, 63% and 53% during the last 25 years. Pancreatic cancer accounts for 1.8% of all cancers, causing 3.9% of all cancer disability- adjusted life years (DALYs) and 4.6% of all cancer deaths. No sex differences can be observed for incidence, prevalence and mortality, whilst DALYs are marginally higher in men. Incidence, prevalence and mortality follow a similar age-related trend, with gradual escalation after 30 years of age, reaching the highest burden after 80 years of age. The DALYs peak between 55 and 74 years, and then decline. The epidemiologic burden is positively associated with socio-demographic status. The largest burden of pancreatic cancers is observed in the East and Asia Pacific region, whilst the lowest is found in the Middle East and North Africa. Pancreatic cancer deaths are expected to increase by ~1.97-fold by the year 2060. CONCLUSIONS Although pancreatic cancer remains relatively infrequent, its clinical, societal and economic burden is noteworthy. Future projections suggest that its burden may double during the next 40 years.

中文翻译：

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胰腺癌的全球负担。

引言 我们在此概述目前全球范围内胰腺恶性肿瘤的流行病学，这些流行病学来自全球健康数据交换 (GHDx) 和世界卫生组织 (WHO) 的资料库。材料和方法 在 GHDx 和 WHO 的官方资料库中进行了收集胰腺癌流行病学信息的电子搜索，然后对检索到的数据进行了分析。结果 总体而言，2017 年全球记录了 447665 例胰腺癌新病例（58.6/百万），全球患病率为 49.8/百万，死亡 441 083 例（57.7/百万）。在过去 25 年中，发病率、流行率和死亡率分别增加了 55%、63% 和 53%。胰腺癌占所有癌症的 1.8%，占所有癌症残疾调整生命年 (DALY) 的 3.9% 和所有癌症死亡的 4.6%。在发病率、流行率和死亡率方面没有观察到性别差异，而男性的 DALYs 略高。发病率、患病率和死亡率遵循与年龄相关的类似趋势，30岁后逐渐升高，80岁后达到最高负担。DALYs 在 55 到 74 岁之间达到峰值，然后下降。流行病学负担与社会人口状况呈正相关。东部和亚太地区的胰腺癌负担最大，而中东和北非地区的胰腺癌负担最低。到 2060 年，胰腺癌死亡人数预计将增加约 1.97 倍。 结论 尽管胰腺癌仍然相对少见，但其临床、社会和经济负担值得注意。