Despite the rise of sophisticated new targeting strategies in cancer chemotherapy, many classic DNA-binding drugs remain on the front line of the therapy against cancer. Based on examples primarily from the author's laboratory, this article reviews the capabilities of several DNA-binding drugs to alter gene expression. Research is ongoing about the molecular bases of the inhibition of gene expression and how alteration of the cellular transcriptome can commit cancer cells to die. The development of a variety of omic techniques allows us to gain insights into the effect of antitumor drugs. Genome-wide approaches provide unbiased genomic data that can facilitate a deeper understanding of the cellular response to DNA-binding drugs. Moreover, the results of large-scale genomic studies are gathered in publicly available databases that can be used in developing precision medicine in cancer treatment.

中文翻译：

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组学时代DNA-药物相互作用的洞察

尽管在癌症化疗中出现了复杂的新靶向策略，但许多经典的 DNA 结合药物仍然处于抗癌治疗的前线。本文主要基于作者实验室的示例，回顾了几种 DNA 结合药物改变基因表达的能力。关于基因表达抑制的分子基础以及细胞转录组的改变如何使癌细胞死亡的研究正在进行中。各种组学技术的发展使我们能够深入了解抗肿瘤药物的作用。全基因组方法提供了无偏见的基因组数据，有助于更深入地了解细胞对 DNA 结合药物的反应。而且，