Background:To investigate the effect of cardiovascular disease (CVD) on the global pandemic, coronavirus disease 2019 (COVID-19), we analyzed the cases of laboratory-confirmed COVID-19 patients in Wuhan.

Methods and Results:Data were extracted from the medical records. SARS-CoV-2 RNA was confirmed by RT-PCR. A total of 33 (53.2%) of 62 cases with CVD, who had higher prevalence of severe COVID-19 compared with non-CVD patients (P=0.027). The median age of all patients was 66.0 (53.3, 73.0) years old. Coronary artery disease (11.3%) and hypertension (38.7%) were the common coexisting CVDs in COVID-19 patients. High-sensitivity cardiac troponin I (hs-cTnI), creatinine, high-density lipoprotein-cholesterol, interleukin-6, C-reactive protein, prothrombin time, and D-dimer levels in the severe COVID-19 with CVD group were higher than in the non-severe COVID-19 with CVD group (P<0.05). For all patients, chest computed tomography (CT) showed ground-glass opacity (66.1%), local (21.0%), bilateral (77.4%), and interstitial abnormalities (4.8%). In COVID-19 patients with CVD, 27 (81.8%) were cured and discharged. 6 (18.2%) remained in hospital, including 2 (3.2%) patients requiring intubation and mechanical ventilation. The hs-cTnI levels in the remaining hospitalized patients were higher than in the discharged patients (P=0.047).

Conclusions:CVDs play a vital role in the disease severity of COVID-19. COVID-19 could result in myocardial injury, which affects the prognosis of COVID-19.

背景：为研究心血管疾病（CVD）对全球大流行性冠状病毒病2019（COVID-19）的影响，我们分析了武汉市经实验室确认的COVID-19患者的病例。

方法和结果：从病历中提取数据。通过RT-PCR确认SARS-CoV-2 RNA。在62例CVD患者中，共有33例（53.2％）与非CVD患者相比，严重COVID-19的患病率更高（P = 0.027）。所有患者的中位年龄为66.0（53.3，73.0）岁。冠状动脉疾病（11.3％）和高血压（38.7％）是COVID-19患者常见的CVD。严重的COVID-19伴CVD组的高敏感性心脏肌钙蛋白I（hs-cTnI），肌酐，高密度脂蛋白胆固醇，白介素-6，C反应蛋白，凝血酶原时间和D-二聚体水平高于在非严重COVID-19合并CVD组中（P <0.05）。对于所有患者，胸部计算机断层扫描（CT）均显示出玻璃杯混浊（66.1％），局部（21.0％），双侧（77.4％）和间质异常（4.8％）。在COVID-19的CVD患者中，治愈出院27例（81.8％）。仍有6名（18.2％）住院，包括2名（3.2％）需要插管和机械通气的患者。其余住院患者的hs-cTnI水平高于出院患者（P = 0.047）。

结论： CVD在COVID-19的疾病严重程度中起着至关重要的作用。COVID-19可能导致心肌损伤，从而影响COVID-19的预后。