Multifunctional nanocarriers have been widely accepted and utilized for biomedical applications, because of their structural regularity, convenient post-modification and controllable structure and morphology. Herein, we reported polydopamine-doped virus-like mesoporous silica coated reduced graphene oxide nanosheets ([email protected]) nanocomposites by a facile oil–water biphase stratification method. The synthesized [email protected] nanocomposites performed excellent biocompatibility and photothermal performance. They could be employed as photoacoustic imaging contrast in vivo. Furthermore, the [email protected] nanocarriers were used for loading the antitumor drug doxorubicin (DOX), the [email protected]@DOX nanocomposites were also demonstrated to be with high inhibition of HepG2 cancer cells, especially with the help of near-infrared irradiation, which were more efficient than single chemotherapy or photothermal therapy. The [email protected]@DOX nanocomposites of this work could be used as photoacoustic imaging and chemo-photothermal synergetic therapy agents, which show a new perspective for clinical tumor diagnosis and therapy.

多功能纳米载体由于其结构规律、方便的后修饰和可控的结构和形态，已被广泛接受并用于生物医学应用。在此，我们通过简便的油水双相分层方法报道了聚多巴胺掺杂的类病毒介孔二氧化硅涂层还原氧化石墨烯纳米片（[电子邮件保护]）纳米复合材料。合成的 [电子邮件保护] 纳米复合材料具有出色的生物相容性和光热性能。它们可以用作体内光声成像对比度。此外，[电子邮件保护]纳米载体用于加载抗肿瘤药物阿霉素（DOX），[电子邮件保护]@DOX纳米复合材料也被证明对HepG2癌细胞具有高度抑制作用，特别是在近红外照射的帮助下，比单一的化学疗法或光热疗法更有效。[email protected]@DOX 纳米复合材料可用作光声成像和化学光热协同治疗剂，为临床肿瘤诊断和治疗提供了新的视角。