Pexophagy is a peroxisome degradation process. The last two steps of penicillin biosynthesis in Penicillium rubens are carried out in peroxisomes. These organelles proliferate in large numbers during this process, so that after the penicillin secretion, their removal is essential as a regulatory mechanism. In this work, two pexophagy modes are described for the high-penicillin producing strain P. rubens P2-32-T, by transmission electron microscopy (TEM) on 24- and 48-h cultures (when maximum penicillin production is achieved). The obtained images show peroxisome phagocytosis by vacuoles in three different ways: macropexophagy, micropexophagy, and a new proposed model: unipexophagy.

中文翻译：

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Penicillium rubens P2-32-T青霉素生物合成过程中的Pexophagy模式

Pexophagy 是一种过氧化物酶体降解过程。红青霉中青霉素生物合成的最后两个步骤是在过氧化物酶体中进行的。这些细胞器在此过程中大量增殖，因此在青霉素分泌后，作为调节机制，去除它们是必不可少的。在这项工作中，通过对 24 小时和 48 小时培养物（达到最大青霉素产量）的透射电子显微镜 (TEM)，描述了高青霉素生产菌株 P. rubens P2-32-T 的两种食道模式。获得的图像以三种不同的方式显示了液泡的过氧化物酶体吞噬作用：巨噬细胞、微巨噬细胞和一种新提出的模型：unipexophagy。