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Low Volume Acute Multi-Joint Resistance Exercise Elicits a Circulating Brain-Derived Neurotrophic Factor Response but Not a Cathepsin B Response in Well-Trained Men.
Applied Physiology, Nutrition, and Metabolism ( IF 2.4 ) Pub Date : 2020-06-12 , DOI: 10.1139/apnm-2019-0854
Trevor K Johnson 1, 1 , Daniel J Belcher 1, 1 , Colby A Sousa 1, 1 , Joseph P Carzoli 1, 1 , Nishant P Visavadiya 1, 1 , Andy V Khamoui 1, 1 , Michael Whitehurst 1, 1 , Michael C Zourdos 1, 1
Affiliation  

Applied Physiology, Nutrition, and Metabolism, Ahead of Print.
This study examined if acute multi-joint resistance exercises (RE; back squat, bench press, and deadlift) to volitional failure elicited a postexercise increase in the circulating response of biomarkers associated with neuroprotection. Thirteen males (age: 24.5 ± 3.8 years, body mass: 84.01 ± 15.44 kg, height: 173.43 ± 8.57 cm, training age: 7.1 ± 4.2 years) performed 4 sets to failure at 80% of a 1-repetition maximum on the squat, bench press, and deadlift in successive weeks. The measured biomarkers were brain-derived neurotrophic factor (BDNF), insulin-like growth factor 1 (IGF-1), cathepsin B (CatB), and interleukin 6 (IL-6). Biomarkers were assessed immediately before and 10-min after exercise. There was a main time effect (pre-exercise: 24.00 ± 0.61 to postexercise: 27.38 ± 0.48 ng/mL; p < 0.01) for BDNF with increases in the deadlift (p = 0.01) and bench press (p = 0.01) conditions, but not in the squat condition (p = 0.21). There was a main time effect (pre-exercise: 0.87 ± 0.16 to postexercise: 2.03 ± 0.32 pg/mL; p < 0.01) for IL-6 with a significant increase in the squat (p < 0.01), but not the bench press (p = 0.88) and deadlift conditions (p = 0.24). No main time effect was observed for either CatB (p = 0.62) or IGF-1 (p = 0.56). In summary, acute multi-joint RE increases circulating BDNF. Further, this investigation is the first to report the lack of a transient change of CatB to an acute RE protocol. Novelty Low-volume RE to failure can increase BDNF. Resistance training does not confer an acute Cat B response.


中文翻译:

低容量急性多关节阻力运动在训练有素的男性中引起循环脑源性神经营养因子反应,但不会引起组织蛋白酶 B 反应。

应用生理学、营养学和代谢,提前出版。
该研究检查了针对意志力衰竭的急性多关节阻力练习(RE;背蹲、卧推和硬拉)是否会引起运动后与神经保护相关的生物标志物的循环反应增加。13 名男性(年龄:24.5 ± 3.8 岁,体重:84.01 ± 15.44 公斤,身高:173.43 ± 8.57 厘米,训练年龄:7.1 ± 4.2 岁)在深蹲中以 1 次最大值的 80% 进行了 4 组失败、卧推和硬拉连续几周。测量的生物标志物是脑源性神经营养因子 (BDNF)、胰岛素样生长因子 1 (IGF-1)、组织蛋白酶 B (CatB) 和白细胞介素 6 (IL-6)。在运动前和运动后 10 分钟立即评估生物标志物。有一个主要的时间效应(运动前:24.00 ± 0.61 到运动后:27.38 ± 0.48 ng/mL;p < 0。01) 对于 BDNF,硬拉 (p = 0.01) 和卧推 (p = 0.01) 条件增加,但在深蹲条件 (p = 0.21) 中没有增加。IL-6 有一个主要的时间效应(运动前:0.87 ± 0.16 到运动后:2.03 ± 0.32 pg/mL;p < 0.01),深蹲显着增加(p < 0.01),但不是卧推(p = 0.88) 和硬拉条件 (p = 0.24)。未观察到 CatB(p = 0.62)或 IGF-1(p = 0.56)的主要时间效应。总之,急性多关节 RE 增加循环 BDNF。此外,这项调查是第一个报告缺乏 CatB 对急性 RE 协议的瞬时变化的调查。新奇低容量 RE 到故障可以增加 BDNF。阻力训练不会产生急性 Cat B 反应。IL-6 有一个主要的时间效应(运动前:0.87 ± 0.16 到运动后:2.03 ± 0.32 pg/mL;p < 0.01),深蹲显着增加(p < 0.01),但不是卧推(p = 0.88) 和硬拉条件 (p = 0.24)。未观察到 CatB(p = 0.62)或 IGF-1(p = 0.56)的主要时间效应。总之,急性多关节 RE 增加循环 BDNF。此外,这项调查是第一个报告缺乏 CatB 对急性 RE 协议的瞬时变化的调查。新奇低容量 RE 到故障可以增加 BDNF。阻力训练不会产生急性 Cat B 反应。IL-6 有一个主要的时间效应(运动前:0.87 ± 0.16 到运动后:2.03 ± 0.32 pg/mL;p < 0.01),深蹲显着增加(p < 0.01),但不是卧推(p = 0.88) 和硬拉条件 (p = 0.24)。未观察到 CatB(p = 0.62)或 IGF-1(p = 0.56)的主要时间效应。总之,急性多关节 RE 增加循环 BDNF。此外,这项调查是第一个报告缺乏 CatB 对急性 RE 协议的瞬时变化的调查。新奇低容量 RE 到故障可以增加 BDNF。阻力训练不会产生急性 Cat B 反应。未观察到 CatB(p = 0.62)或 IGF-1(p = 0.56)的主要时间效应。总之,急性多关节 RE 增加循环 BDNF。此外,这项调查是第一个报告缺乏 CatB 对急性 RE 协议的瞬时变化的调查。新奇低容量 RE 到故障可以增加 BDNF。阻力训练不会产生急性 Cat B 反应。未观察到 CatB(p = 0.62)或 IGF-1(p = 0.56)的主要时间效应。总之,急性多关节 RE 增加循环 BDNF。此外,这项调查是第一个报告缺乏 CatB 对急性 RE 协议的瞬时变化的调查。新奇低容量 RE 到故障可以增加 BDNF。阻力训练不会产生急性 Cat B 反应。
更新日期:2020-06-12
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