One of the hallmarks of cancer cells is increased energy requirements associated with the higher rate of cellular proliferative activity. Metabolic changes in rapidly dividing cancer cells are closely associated with increased uptake of glucose and abnormal activity of lactate dehydrogenase (LDH), which regulates the processing of glucose to lactic acid. As serum LDH levels were found to be commonly increased in cancer patients and correlated with poor clinical outcome and resistance to therapy, the determination of LDH has become a standard supportive tool in diagnosing cancers or monitoring the effects of cancer treatment. The aim of this review is to summarize the current knowledge about methods and the practical utility for measuring both the total LDH and LDH isoenzymatic activities in the diagnosis, prognosis and prediction of cancer diseases.

中文翻译：

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乳酸脱氢酶测量在当前肿瘤学实践中的有用性。

癌细胞的标志之一是与更高水平的细胞增殖活性相关的能量需求增加。快速分裂的癌细胞中的代谢变化与葡萄糖摄取的增加和乳酸脱氢酶（LDH）的异常活性密切相关，后者调节葡萄糖向乳酸的转化。由于发现血清LDH水平通常在癌症患者中升高，并且与不良的临床结局和对治疗的抵抗性相关，因此LDH的测定已成为诊断癌症或监测癌症治疗效果的标准支持工具。这篇综述的目的是总结有关在诊断中同时测量总LDH和LDH同工酶活性的方法和实际应用的知识，