Owing to their unique electrical and optical properties, two-dimensional transition metal dichalcogenides have been extensively studied for their potential applications in biosensing. However, simultaneous utilization of both optical and electrical properties has been overlooked, yet it can offer enhanced accuracy and detection versitility. Here, we demonstrate a dual-mode optoelectronic biosensor based on monolayer molybdenum disulfide (MoS2) capable of producing simultaneous electrical and optical readouts of biomolecular signals. On a single platform, the biosensor exhibits a tunable photonic Fano-type optical resonance while also functioning as a field-effect transistor (FET) based on a optically transparent gate electrode. Furthermore, chemical vapor deposition grown MoS2 provides a clean surface for direct immobilization of a water-soluble variant of the μ-opioid receptor (wsMOR), via a nickel ion-mediated linker chemistry. We utilize a synthetic opioid peptide to show the operation of the electronic and optical sensing modes. The responses of both modes exhibit a similar trend with dynamic ranges of four orders of magnitude and detection limits of <1 nM. Our work explores the potential of a versatile multimodal sensing platform enabled by monolayer MoS2, since the integration of electrical and optical sensors on the same chip can offer flexibility in read-out and improve the accuracy in detection of low concentration targets.

中文翻译：

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MoS2 双模式光电生物传感器使用 μ-阿片受体的水溶性变体进行阿片肽检测。


由于其独特的电学和光学性质，二维过渡金属二硫属化物因其在生物传感中的潜在应用而被广泛研究。然而，同时利用光学和电学特性却被忽视了，但它可以提供更高的精度和检测多功能性。在这里，我们展示了一种基于单层二硫化钼（MoS2）的双模式光电生物传感器，能够同时产生生物分子信号的电学和光学读数。在单一平台上，生物传感器表现出可调谐光子 Fano 型光学谐振，同时还充当基于光学透明栅电极的场效应晶体管 (FET)。此外，化学气相沉积生长的 MoS2 提供了一个干净的表面，可通过镍离子介导的连接化学直接固定 μ-阿片受体 (wsMOR) 的水溶性变体。我们利用合成阿片肽来展示电子和光学传感模式的操作。两种模式的响应表现出相似的趋势，动态范围为四个数量级，检测限为 <1 nM。我们的工作探索了由单层 MoS2 实现的多功能多模态传感平台的潜力，因为将电气和光学传感器集成在同一芯片上可以提供读出的灵活性并提高低浓度目标检测的准确性。