Background With atrial fibrillation (AF) the risk of stroke is 4.2-fold increased to a comparable population without AF. This risk decreases by up to 70% if AF is detected early enough and effective stroke preventive measures are taken as recommended by international guidelines. Long-term studies found large number of subjects with undiagnosed AF. Preventicus Heartbeats” is a hands-on screening tool for use on smartphone to diagnose AF with high sensitivity and specificity. The aim of this study is to research the cost-effectiveness of systematic screening for AF with this smartphone application. Method Employing a Markov model we analysed the cost-effectiveness of the “Preventicus Heartbeats” screening for Germany, i.e. from the perspective of German statutory sick funds. Results For a cohort of 10,000 insured 75-year-old the use of the diagnostic app could avoid 60 strokes in the remaining lifetime thereof 32 strokes in the next four years. Former models have applied similar cohorts. The same cohort showed an increase in quality-adjusted life years (QALY) in the remaining lifetime of 165 QALYs in the scenario with screening versus. without screening and a decrease in discounted lifetime costs (including risk compensation effects) of €129 per participant (€148 for male, €114 for female participants). Conclusions The modelling demonstrates the health benefits and economic effects of an implementation of a systematic screening on AF with “Preventicus Heartbeats”, given the perspective of the German payer, the statutory health care system.

中文翻译：

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从德国法定健康保险的角度研究预防性房颤的成本效益分析模型。

背景对于没有房颤的可比人群，房颤（AF）可使中风的风险增加4.2倍。如果及早发现房颤并按照国际指南的建议采取有效的中风预防措施，则这种风险最多可降低70％。长期研究发现大量未诊断为AF的受试者。“预防心跳”是一种动手筛查工具，可用于智能手机，以高灵敏度和特异性诊断房颤。这项研究的目的是研究使用此智能手机应用程序进行AF系统筛选的成本效益。方法采用马尔可夫模型，我们从德国法定病基金的角度分析了对德国“预防性心跳”筛查的成本效益。结果对于10个群组，000位75岁的被保险人使用诊断应用程序可以在未来四年内避免剩余60次中风，而在其剩余寿命中避免32次中风。以前的模型采用了类似的队列。在筛选与筛选的情况下，同一队列显示在165个QALY的剩余生命中，质量调整生命年（QALY）有所增加。无需筛查，每位参与者的终生贴现成本（包括风险补偿效应）减少为129欧元（男性148欧元，女性114欧元）。结论该模型展示了以德国付款人（法定医疗保健系统）的观点进行“预防性心跳”对房颤进行系统筛查的健康益处和经济效果。以前的模型采用了类似的队列。在筛查与筛查相比，同一队列显示在165个QALY的剩余生命中，质量调整生命年（QALY）有所增加。无需筛查，每位参与者的终生贴现成本（包括风险补偿效应）减少为129欧元（男性148欧元，女性114欧元）。结论该模型展示了以德国付款人（法定医疗保健系统）的观点进行“预防性心跳”对房颤进行系统筛查的健康益处和经济效果。以前的模型采用了类似的队列。在筛查与筛查相比，同一队列显示在165个QALY的剩余生命中，质量调整生命年（QALY）有所增加。无需筛查，每位参与者的终生贴现成本（包括风险补偿效果）减少了129欧元（男性148欧元，女性114欧元）。结论该模型展示了以德国付款人（法定医疗保健系统）的观点进行“预防性心跳”对房颤进行系统筛查的健康益处和经济效果。无需筛查，每位参与者的终生贴现成本（包括风险补偿效应）减少为129欧元（男性148欧元，女性114欧元）。结论该模型展示了以德国付款人（法定医疗保健系统）的观点进行“预防性心跳”对房颤进行系统筛查的健康益处和经济效果。无需筛查，每位参与者的终生贴现成本（包括风险补偿效果）减少了129欧元（男性148欧元，女性114欧元）。结论该模型展示了以德国付款人（法定医疗保健系统）的观点进行“预防性心跳”对房颤进行系统筛查的健康益处和经济效果。