Ribonucleic acid (RNA) molecules can be easily attacked by reactive oxygen species (ROS), which are produced during normal cellular metabolism and under various oxidative stress conditions. Numerous findings report that the amount of cellular 8-oxoG, the most abundant RNA damage biomarker, is a promising target for the sensitive measurement of oxidative stress and aging-associated diseases, including neuropsychiatric disorders. Most importantly, available data suggest that RNA oxidation has important implications for various signaling pathways and gene expression regulation in aging-related diseases, highlighting the necessity of using combinations of RNA oxidation adducts in both experimental studies and clinical trials. In this review, we primarily describe evidence for the effect of oxidative stress on RNA integrity modulation and possible quality control systems. Additionally, we discuss the profiles and clinical implications of RNA oxidation products that have been under intensive investigation in several aging-associated medical disorders.

中文翻译：

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当前关于氧化 RNA 损伤在衰老研究中的临床意义的观点：挑战和机遇。

核糖核酸（RNA）分子很容易受到活性氧（ROS）的攻击，活性氧是在正常细胞代谢和各种氧化应激条件下产生的。大量研究结果表明，细胞 8-oxoG（最丰富的 RNA 损伤生物标志物）的量是敏感测量氧化应激和衰老相关疾病（包括神经精神疾病）的有希望的目标。最重要的是，现有数据表明，RNA 氧化对衰老相关疾病中的各种信号通路和基因表达调控具有重要影响，强调了在实验研究和临床试验中使用 RNA 氧化加合物组合的必要性。在这篇综述中，我们主要描述了氧化应激对 RNA 完整性调节和可能的质量控制系统影响的证据。此外，我们还讨论了 RNA 氧化产物的概况和临床意义，这些产物已在几种与衰老相关的医学疾病中得到深入研究。