Guided bone regeneration (GBR) is an effective alveolar ridge reconstruction technique used before or at implant placement. The combination of various barrier membranes and bone substitutes has been employed. This study aimed to perform a preliminarily evaluation of the safety and performance of a new nonabsorbable bi-layered porous polyethylene (PPE) membrane, in combination with a freeze-dried cortical bone allograft in posterior mandibular ridge augmentation. Fifteen adults who had combined posterior mandibular defects were included for ridge augmentation via GBR using PPE membrane and allograft before implant placement. The keratinized mucosa width (KW), ridge width (RW), ridge height (RH), distance from measurement matrix to bone (DMB), and horizontal alveolar width at 14.0 mm apical to the occlusal plane (HAW) were clinically measured at 15 intended implant sites before and after the augmentation. Fifteen biopsy specimens were harvested at the implant sites for histological analysis. All the subjects completed the whole study. The KW and RH showed minor gains by 0.2 ± 1.4 mm and 0.9 ± 2.3 mm respectively; however, no statistically significant differences were found between, before, and after the augmentation (P > 0.05). In contrast, the RW and HAW significantly increased by 4.8 ± 1.6 mm and 2.3 ± 1.7 mm, respectively, (P ≤ 0.001), while DMB significantly decreased by 1.0 ± 0.8 mm after treatment (P < 0.001). Histological analysis revealed that allograft underwent active bone remodeling. The PPE membrane was adequately safe and efficient to use with allograft in GBR for the reconstruction of combined ridge defects. Although some complications were observed, these were manageable and subsequently lead to successful implant placement for all the subjects. However, further randomized controlled trials are still needed to confirm these findings.

引导骨再生（GBR）是在植入物放置之前或放置时使用的有效牙槽al重建技术。已经采用了各种屏障膜和骨替代物的组合。这项研究旨在初步评估新型不可吸收双层多孔聚乙烯（PPE）膜的安全性和性能，并结合冻干皮质同种异体骨植入后下颌后突。15名合并后下颌骨缺损的成年人在植入植入物之前通过PPE膜和同种异体移植物通过GBR进行了隆脊。角化黏膜宽度（KW），脊宽（RW），脊高（RH），从测量矩阵到骨骼的距离（DMB）以及水平牙槽宽度为14。在隆突前后，在15个预期的植入部位临床测量了距咬合面（HAW）顶端0 mm的位置。在植入部位收集了15个活检标本用于组织学分析。所有受试者都完成了整个研究。KW和RH分别显示出0.2±1.4 mm和0.9±2.3 mm的较小增益；但是，在增强前后，增强前后均未发现统计学上的显着差异（P > 0.05）。与此相反，RW和HAW显著和增加了4.8±1.6毫米2.3±1.7毫米，分别，（P ≤0.001），而DMB处理后显著减少1.0±0.8毫米（P <0.001）。组织学分析表明，同种异体移植经历了主动的骨重塑。PPE膜对于同种异体移植在GBR中使用是足够安全和​​有效的，可用于重建合并的脊骨缺损。尽管观察到一些并发症，但这些并发症是可以控制的，并随后导致所有受试者成功植入植入物。但是，仍然需要进一步的随机对照试验来证实这些发现。