Objective. The vagus nerve has been implicated in a variety of immune responses, and the number of studies using mouse models to unravel key mechanisms has increased. However, as of yet, there is no electrode that can chronically record neural activity from the mouse vagus nerve due to its small diameter. Such recordings are critical to understand the role of these biomarkers for translational research. Approach. In this study, we developed a methodology for surgically implanting the wrappable microwires onto the vagus nerve of mice. Similar to a cuff electrode, we wrapped de-insulated ends of microwires around the vagus nerve and re-insulated them on the nerve with Kwik-Sil. The recording fidelity of the wrappable microwire on the vagus nerve was validated in an acute, anesthetized model by comparing performance to commercially-available electrodes. A chronic, awake mouse model was then developed to record spontaneous compound action potentials (CAPs). Main re...

中文翻译：

---

一种新型的微丝界面，用于慢性清醒鼠模型中的小直径周围神经。

目的。迷走神经与多种免疫反应有关，并且使用小鼠模型揭示关键机制的研究数量有所增加。但是，由于直径小，至今还没有电极可以长期记录小鼠迷走神经的神经活动。此类记录对于了解这些生物标记物在转化研究中的作用至关重要。方法。在这项研究中，我们开发了一种通过手术将可包裹微丝植入小鼠迷走神经的方法。与袖带电极类似，我们将迷走神经周围的微丝去绝缘末端包裹起来，并用Kwik-Sil将它们重新绝缘在神经上。迷走神经上可包裹微丝的记录保真度已在急性，麻醉模型，将其性能与市售电极进行比较。然后建立了一个慢性的，醒着的小鼠模型，以记录自发的复合动作电位（CAPs）。主要...