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Photoresponsive Biomimetic Protocells for Near-Infrared-LightRegulated Phototheranostics
CCS Chemistry ( IF 9.4 ) Pub Date : 2019-10-04 , DOI: 10.31635/ccschem.019.20180033 Ling Liang 1 , Yawei Tang 1 , Xiaoxiao Hu 1 , Jie Wang 2 , Shehua Xiao 1 , Dan Li 1 , Linna Fu 1 , Zhihao Li 2 , Quan Yuan 1, 2
CCS Chemistry ( IF 9.4 ) Pub Date : 2019-10-04 , DOI: 10.31635/ccschem.019.20180033 Ling Liang 1 , Yawei Tang 1 , Xiaoxiao Hu 1 , Jie Wang 2 , Shehua Xiao 1 , Dan Li 1 , Linna Fu 1 , Zhihao Li 2 , Quan Yuan 1, 2
Affiliation
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Nature has created complex living systems with
outstanding structure and remarkable function.
Constructing biomimetic systems that rival living
organisms has attracted considerable research interest
in research fields of self-assembly and bionic science.
Inspired by the composition of photosynthetic
bacteria, we have designed artificial photoresponsive
protocells through capsulation of upconversion
nanoparticles@black phosphorus quantum dots
(UCNPs@BPQDs) within aptamer-modified liposome
(Apt-Lip) to form UCNPs@BPQDs@Apt-Lip (UBAL).
The UBAL protocells with near-infrared-lightharvesting
capability actively and efficiently convert
light energy into chemical and heat energy. Furthermore,
the successful application of the protocells to
malignant tumors in vivo exhibited near-infraredlight-mediated
targeted combined photodynamic
and photothermal synergistic therapy. Our demonstration
of operative protocells not only represents
a method for fabricating light-harvesting systems
based on nanoassembly, but also provides a promising
step toward photosynthetic protocells with
integrated cell-like structure and light-harvesting
function for nanomedicine.
中文翻译：
用于近红外光调控的光敏仿生原细胞
大自然创造了具有卓越结构和卓越功能的复杂生物系统。建立可与生物体竞争的仿生系统，在自组装和仿生科学的研究领域中引起了相当大的研究兴趣。受光合细菌组成的启发，我们通过在适配体修饰脂质体（Apt-Lip）中将上转换纳米粒子@黑磷量子点（UCNPs @ BPQDs）封装成UCNPs @ BPQDs @ Apt-Lip（UBAL），设计了人工光响应性原始细胞）。具有近红外光收集能力的UBAL原型电池可以主动，有效地将光能转换为化学能和热能。此外，原生细胞在体内恶性肿瘤上的成功应用表现出近红外介导的靶向联合光动力和光热协同治疗。我们对操作性原始细胞的演示不仅代表了一种基于纳米组装的光收集系统的制造方法，而且为朝着具有集成细胞样结构和纳米药物光收集功能的光合原始细胞提供了有希望的一步。
更新日期：2020-06-24
中文翻译：
用于近红外光调控的光敏仿生原细胞
大自然创造了具有卓越结构和卓越功能的复杂生物系统。建立可与生物体竞争的仿生系统，在自组装和仿生科学的研究领域中引起了相当大的研究兴趣。受光合细菌组成的启发，我们通过在适配体修饰脂质体（Apt-Lip）中将上转换纳米粒子@黑磷量子点（UCNPs @ BPQDs）封装成UCNPs @ BPQDs @ Apt-Lip（UBAL），设计了人工光响应性原始细胞）。具有近红外光收集能力的UBAL原型电池可以主动，有效地将光能转换为化学能和热能。此外，原生细胞在体内恶性肿瘤上的成功应用表现出近红外介导的靶向联合光动力和光热协同治疗。我们对操作性原始细胞的演示不仅代表了一种基于纳米组装的光收集系统的制造方法，而且为朝着具有集成细胞样结构和纳米药物光收集功能的光合原始细胞提供了有希望的一步。
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