Structural and Functional Tailoring of Melanin-Like Polydopamine Radical Scavengers,CCS Chemistry

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Structural and Functional Tailoring of Melanin-Like Polydopamine Radical Scavengers
CCS Chemistry ( IF 9.4 ) Pub Date : 2020-02-26 , DOI: 10.31635/ccschem.020.201900077
Peng Yang ₁ , Zhipeng Gu ₁ , Fang Zhu ₁ , Yiwen Li ₁

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Melanin is a ubiquitous but poorly understood polymeric, dark brown to black pigment biomaterial found both in nature and by organic synthesis. Its structural heterogeneity and disordered covalent/noncovalent interactions make it a grand challenge to tune and improve the physical and biological properties of both melanin sources. Herein, we report a facile one-pot fabrication approach for synthetic melanins with controlled size and composition via copolymerization of dopamine and basic amino acid such as arginine in an aqueous solution. The resulting arginine-doped polydopamine melanin-like nanoparticles possess less ordered nonplanar microstructures within the particles, whereas the conventional polydopamine-based melanins contain a variety of compact π-stacked microstructures. The assembly of these distinct polymeric microstructures could lead the preceding ones for greater accessibility to free radicals, with resultant stronger free-radical scavenging effect, and thus, exhibit superior antioxidant performance toward cellular oxidative stress. This work has inspired us to continue to fabricate new synthetic melanin pigments with tunable and improved functions by rational structural tailoring.

中文翻译：

黑色素类聚多巴胺自由基清除剂的结构和功能定制

黑色素是在自然界和通过有机合成发现的普遍存在的但知之甚少的聚合性，深棕色至黑色颜料生物材料。它的结构异质性和无序的共价/非共价相互作用使调节和改善黑色素来源的物理和生物学特性成为一个巨大的挑战。在本文中，我们报告了一种简单的一锅法制造方法，该方法通过多巴胺和碱性氨基酸（例如精氨酸）在水溶液中的共聚，来控制尺寸和组成的合成黑色素。所得精氨酸掺杂的聚多巴胺黑色素样纳米颗粒在颗粒内具有较少有序的非平面微结构，而常规的基于聚多巴胺的黑色素包含多种紧密的π堆积的微结构。这些不同的聚合物微结构的组装可以使前面的微结构更容易进入自由基，从而产生更强的自由基清除作用，从而对细胞氧化应激表现出优异的抗氧化性能。这项工作启发了我们继续通过合理的结构剪裁来制造具有可调和改进功能的新型合成黑色素颜料。

更新日期：2020-06-24

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