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Antimicrobial Rubber Nanocapsule-Based Iodophor Promotes Wound Healing
CCS Chemistry ( IF 9.4 ) Pub Date : 2020-04-06 , DOI: 10.31635/ccschem.020.201900101 Ruiting Li 1 , Zhen Wang 1 , Xiaodong Lian 1 , Xiaohua Hu 2 , Yapei Wang 1
CCS Chemistry ( IF 9.4 ) Pub Date : 2020-04-06 , DOI: 10.31635/ccschem.020.201900101 Ruiting Li 1 , Zhen Wang 1 , Xiaodong Lian 1 , Xiaohua Hu 2 , Yapei Wang 1
Affiliation
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Povidone–iodine has been leading the market of clinical disinfectants worldwide since the last century but has turned a blind eye to its cytotoxic effect on the cells of the human tissue. In this study, a commercial povidone–iodine, though considered an excellent antibacterial agent, was found to have a negative influence on mammal cell growth and wound healing in preclinical trials. At the early stage of wound treatment, it even severely deteriorated the wound and enlarged the wound area. However, our newly formulated iodophors, based on rubber nanoparticles, were able to discriminate between human and bacterial cells by inhibiting the cytotoxicity damage caused by iodine to mammalian tissue and vigorously, killed the bacterial cells, thereby, presenting as superior performers of wound care, compared with povidone–iodine. We took advantage of a redox combination of an emulsion complex loaded with iodine to solidify a trans-polyisoprene rubber into nanocapsules. Specifically, our fabricated class of rubber nanocapsules proved to be capable of promoting remarkable cell proliferation and wound recovery, thereby, serving as a promising candidate for biocompatible and healing-favored wound disinfection agents in place of povidone–iodine.
中文翻译：
抗菌橡胶纳米胶囊为基础的碘伏促进伤口愈合
自上个世纪以来，聚维酮碘一直领导着全球临床消毒剂市场，但对它对人体组织细胞的细胞毒性作用却视而不见。在这项研究中，商用聚维酮碘虽然被认为是一种出色的抗菌剂，但在临床前试验中发现它对哺乳动物细胞的生长和伤口愈合具有负面影响。在伤口治疗的早期，它甚至严重恶化了伤口并扩大了伤口面积。但是，我们新开发的基于橡胶纳米粒子的碘伏能够通过抑制碘对哺乳动物组织造成的细胞毒性损害来区分人细胞和细菌细胞，并强烈杀死细菌细胞，从而在伤口护理方面表现卓越，与聚维酮碘比较。我们利用载有碘的乳液复合物的氧化还原组合来将反式聚异戊二烯橡胶固化成纳米胶囊。特别是，我们制造的一类橡胶纳米胶囊被证明能够促进显着的细胞增殖和伤口恢复，因此，它是代替聚维酮-碘的具有生物相容性和有利于愈合的伤口消毒剂的有希望的候选者。
更新日期：2020-06-24
中文翻译：
抗菌橡胶纳米胶囊为基础的碘伏促进伤口愈合
自上个世纪以来，聚维酮碘一直领导着全球临床消毒剂市场，但对它对人体组织细胞的细胞毒性作用却视而不见。在这项研究中，商用聚维酮碘虽然被认为是一种出色的抗菌剂，但在临床前试验中发现它对哺乳动物细胞的生长和伤口愈合具有负面影响。在伤口治疗的早期，它甚至严重恶化了伤口并扩大了伤口面积。但是，我们新开发的基于橡胶纳米粒子的碘伏能够通过抑制碘对哺乳动物组织造成的细胞毒性损害来区分人细胞和细菌细胞，并强烈杀死细菌细胞，从而在伤口护理方面表现卓越，与聚维酮碘比较。我们利用载有碘的乳液复合物的氧化还原组合来将反式聚异戊二烯橡胶固化成纳米胶囊。特别是，我们制造的一类橡胶纳米胶囊被证明能够促进显着的细胞增殖和伤口恢复，因此，它是代替聚维酮-碘的具有生物相容性和有利于愈合的伤口消毒剂的有希望的候选者。
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