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Magnesium-based layered double hydroxide nanosheets: a new bone repair material with unprecedented osteogenic differentiation performance.
Nanoscale ( IF 5.8 ) Pub Date : 2020-06-23 , DOI: 10.1039/d0nr03387a Yingjie Wang 1 , Xuan Mei 2 , Yanyan Bian 1 , Tingting Hu 2 , Xisheng Weng 1 , Ruizheng Liang 2 , Min Wei 2
Nanoscale ( IF 5.8 ) Pub Date : 2020-06-23 , DOI: 10.1039/d0nr03387a Yingjie Wang 1 , Xuan Mei 2 , Yanyan Bian 1 , Tingting Hu 2 , Xisheng Weng 1 , Ruizheng Liang 2 , Min Wei 2
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Osteonecrosis of femoral head (ONFH) has been one of the most common diseases, and thus the development of novel biomaterials with superior osteogenic ability is the key issue. In this work, Yb-containing MgAl-layered double hydroxide (LDH) monolayer nanosheets (MgAlYb-LDHs) were designed and synthesized and were used as a new biomaterial with outstanding osteogenic differentiation ability. The LDH monolayer nanosheets gave a high loading content (LC) of 197% for alendronate (AL) with an encapsulation efficiency (EE) of 98.6%. Notably, outstanding in vitro osteogenic differentiation performance of MgAlYb-LDHs was demonstrated in the transcriptional level of Collagen I, with a 3000-fold enhancement compared with the blank control. For in vivo tests with rabbits, the total volume of bone regeneration after treatment with the LDH group was 2.77 and 1.41 times larger than that with the negative control group and positive control group (autologous bone graft, clinical gold standard) at 8 weeks postoperatively. In addition, with the degradation of AL/LDHs, the bone mass density (BMD) of the femoral head increased by 1.52 times compared with that for the positive control group at 8 weeks postoperatively. Therefore, this work provides a new perspective for the design and preparation of 2D monolayer MgAlYb-LDHs and their drug formulation (AL/LDHs), which show great promise in ONFH accompanied by osteoporosis.
中文翻译：
镁基层状双氢氧化物纳米片：一种新型的骨修复材料，具有前所未有的成骨分化性能。
股骨头坏死（ONFH）已成为最常见的疾病之一，因此开发具有优异成骨能力的新型生物材料成为关键问题。在这项工作中，设计并合成了含Yb的MgAl层状双氢氧化物（LDH）单层纳米片（MgAlYb-LDHs），并将其用作具有出色成骨分化能力的新型生物材料。LDH单层纳米片对阿仑膦酸盐（AL）的负载量（LC）为197％，封装效率（EE）为98.6％。值得注意的是，MgAlYb-LDHs的体外成骨分化性能在胶原蛋白I的转录水平上得到了证明，与空白对照组相比，增强了3000倍。对于体内在兔实验中，LDH组术后8周的骨再生总量为阴性对照组和阳性对照组（自体骨移植，临床金标准）的2.77倍和1.41倍。另外，随着AL / LDHs的降解，股骨头的骨密度（BMD）在术后8周比阳性对照组增加了1.52倍。因此，这项工作为二维单层MgAlYb-LDHs及其药物制剂（AL / LDHs）的设计和制备提供了新的视角，在伴随骨质疏松的ONFH中显示出广阔的前景。
更新日期：2020-06-23
中文翻译：
镁基层状双氢氧化物纳米片：一种新型的骨修复材料，具有前所未有的成骨分化性能。
股骨头坏死（ONFH）已成为最常见的疾病之一，因此开发具有优异成骨能力的新型生物材料成为关键问题。在这项工作中，设计并合成了含Yb的MgAl层状双氢氧化物（LDH）单层纳米片（MgAlYb-LDHs），并将其用作具有出色成骨分化能力的新型生物材料。LDH单层纳米片对阿仑膦酸盐（AL）的负载量（LC）为197％，封装效率（EE）为98.6％。值得注意的是，MgAlYb-LDHs的体外成骨分化性能在胶原蛋白I的转录水平上得到了证明，与空白对照组相比，增强了3000倍。对于体内在兔实验中，LDH组术后8周的骨再生总量为阴性对照组和阳性对照组（自体骨移植，临床金标准）的2.77倍和1.41倍。另外，随着AL / LDHs的降解，股骨头的骨密度（BMD）在术后8周比阳性对照组增加了1.52倍。因此，这项工作为二维单层MgAlYb-LDHs及其药物制剂（AL / LDHs）的设计和制备提供了新的视角，在伴随骨质疏松的ONFH中显示出广阔的前景。
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