Covalent organic frameworks (COFs) represent a promising class of crystalline porous materials in various fields, but their applications as biomaterials are usually limited by the large sizes and low colloid stability in aqueous solution. Inspired by the biomimetic mineralization strategies for preparing nanoparticles, herein a homogeneous and stable porphyrin-based COF material (COF-B) has been developed with the assistance of bovine serum albumin (BSA), which exhibits both photothermal and photodynamic activity under the excitation of a laser at a single wavelength. COF-B possesses not only good water dispersibility, but also robust photostability and biocompatibility. Moreover, COF-B shows excellent phototherapy efficiency with effective inhibition or even complete elimination of tumors upon irradiation. This protein-assisted synthesis of COF materials propels the preparation of stable nanoscale COFs and the application of COFs as highly efficient biomedical materials.

中文翻译：

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蛋白质辅助合成的纳米级共价有机骨架，用于癌症的光疗

共价有机骨架（COFs）在各个领域代表着有前景的一类结晶多孔材料，但是它们作为生物材料的应用通常受限于水溶液中的大尺寸和低胶体稳定性。受仿生矿化策略用于制备纳米颗粒的启发，本文在牛血清白蛋白（BSA）的帮助下开发了均一且稳定的基于卟啉的COF材料（COF-B），在牛血清白蛋白（BSA）的激发下它具有光热和光动力活性。单一波长的激光。COF-B不仅具有良好的水分散性，而且还具有强大的光稳定性和生物相容性。而且，COF-B显示出优异的光疗效率，在辐射后可有效抑制甚至完全消除肿瘤。