Purpose Plasma-Lyte is a balanced, crystalloid intravenous fluid which has been shown to avoid the hyperchloremic metabolic acidosis associated with 0.9% sodium chloride. Data on physical, pH and chemical compatibility with other medicines are essential. Methods The compatibility of adrenaline, dobutamine, dopamine, furosemide, midazolam, morphine and milrinone with Plasma-Lyte 148 (PLA) and Plasma-Lyte 148 with 5% glucose (PLA-G) was investigated. Control solutions were 0.9% sodium chloride and 5% glucose. Chemical stability was defined as < 5% concentration change with high-performance liquid chromatography (HPLC). Physical compatibility was assessed by checking for colour changes and precipitate formation. The pH of the admixtures was considered acceptable if between 5 and 9 at all time points. Six repeats were carried out for HPLC, 2 for physical compatibility checks and pH measurements, with all admixtures being tested at 0, 2 and 24 h after mixing. Results All combinations were found to be chemically stable at 0, 2 and 24 h apart from furosemide with PLA-G at 24 h and midazolam with PLA or PLA-G at both 2 and 24 h. Only midazolam was physically incompatible when mixed with both Plasma-Lyte solutions. The pH remained stable in all admixtures, although not all pH values recorded were within the range of 5–9. Conclusion All drugs excluding furosemide and midazolam were shown to be chemically, physically and pH stable at the tested concentrations when diluted with PLA and PLA-G.

中文翻译：

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Plasma-Lyte 148 和 Plasma-Lyte 148 + 5% 葡萄糖与常用重症监护药物相容


目的 Plasma-Lyte 是一种平衡的晶体静脉注射液，已被证明可以避免与 0.9% 氯化钠相关的高氯性代谢性酸中毒。与其他药物的物理、pH 和化学相容性数据至关重要。方法 研究肾上腺素、多巴酚丁胺、多巴胺、速尿、咪达唑仑、吗啡和米力农与 Plasma-Lyte 148 (PLA) 和 Plasma-Lyte 148 含 5% 葡萄糖 (PLA-G) 的配伍性。对照溶液为0.9%氯化钠和5%葡萄糖。化学稳定性定义为高效液相色谱 (HPLC) 测定的浓度变化< 5%。通过检查颜色变化和沉淀形成来评估物理相容性。如果在所有时间点混合物的 pH 值在 5 和 9 之间，则认为混合物的 pH 值是可接受的。 HPLC 重复 6 次，物理相容性检查和 pH 测量重复 2 次，所有混合物在混合后 0、2 和 24 小时进行测试。结果发现所有组合在 0、2 和 24 小时内化学稳定，速尿与 PLA-G 的化学稳定性不同，咪达唑仑与 PLA 或 PLA-G 的化学稳定性均为 24 小时和 24 小时。只有咪达唑仑与两种 Plasma-Lyte 溶液混合时在物理上不相容。尽管并非所有记录的 pH 值都在 5-9 范围内，但所有外加剂的 pH 值均保持稳定。结论 除呋塞米和咪达唑仑外，所有药物在用 PLA 和 PLA-G 稀释时在测试浓度下化学、物理和 pH 值均稳定。