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Recent advances in improving tumor-targeted delivery of imaging nanoprobes.
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-06-23 , DOI: 10.1039/d0bm00761g Qianyi Zhang 1 , Jieying Liang , Sung Lai Jimmy Yun , Kang Liang , Dayong Yang , Zi Gu
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-06-23 , DOI: 10.1039/d0bm00761g Qianyi Zhang 1 , Jieying Liang , Sung Lai Jimmy Yun , Kang Liang , Dayong Yang , Zi Gu
Affiliation
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Tumor-targeted delivery of imaging nanoprobes provides a promising approach for the precision imaging diagnosis of cancers. Nanoprobes with desired bio-nano interface properties can preferably enter tumor tissues through the vascular endothelium, penetrate into deep tissues, and detect target lesions. Surface engineering of nanoparticles offers a critical strategy to improve tumor-targeting capacities of nanoprobes. Improvements to the efficacy of targeted nanoprobes have been intensively explored and much of this work centers on the selection of suitable targeting ligands. Herein, in this review, various recent strategies based on different targeting ligands to improve tumor-targeting of imaging nanoprobes have been developed, ranging from small molecule ligands to biomimetic coatings, with highlights on emerging coating techniques using cell membranes and dual-targeting ligands. In particular, construction and surface modification methods, targeting capacities, and imaging/theranostic performance with key issues and potential questions have been described and discussed together with considerations for future development and innovations.
中文翻译：
在改善成像纳米探针的肿瘤靶向递送方面的最新进展。
成像纳米探针的肿瘤靶向递送为癌症的精确成像诊断提供了一种有前途的方法。具有期望的生物-纳米界面特性的纳米探针可以优选地通过血管内皮进入肿瘤组织，渗入深部组织，并检测靶病变。纳米粒子的表面工程学提供了提高纳米探针对肿瘤的靶向能力的关键策略。已经深入研究了靶向纳米探针功效的提高，并且许多工作集中在选择合适的靶向配体上。本文中，本综述基于小分子配体到仿生涂层，开发了各种基于不同靶向配体的新型策略，以改善成像纳米探针的肿瘤靶向性。重点介绍了使用细胞膜和双重靶向配体的新兴涂层技术。尤其是，已经对结构和表面改性方法，目标能力以及具有关键问题和潜在问题的成像/热成像性能进行了描述和讨论，并考虑了未来的发展和创新。
更新日期：2020-07-28
中文翻译：
在改善成像纳米探针的肿瘤靶向递送方面的最新进展。
成像纳米探针的肿瘤靶向递送为癌症的精确成像诊断提供了一种有前途的方法。具有期望的生物-纳米界面特性的纳米探针可以优选地通过血管内皮进入肿瘤组织，渗入深部组织，并检测靶病变。纳米粒子的表面工程学提供了提高纳米探针对肿瘤的靶向能力的关键策略。已经深入研究了靶向纳米探针功效的提高，并且许多工作集中在选择合适的靶向配体上。本文中，本综述基于小分子配体到仿生涂层，开发了各种基于不同靶向配体的新型策略，以改善成像纳米探针的肿瘤靶向性。重点介绍了使用细胞膜和双重靶向配体的新兴涂层技术。尤其是，已经对结构和表面改性方法，目标能力以及具有关键问题和潜在问题的成像/热成像性能进行了描述和讨论，并考虑了未来的发展和创新。
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