Nickel nanoparticles (Ni-NPs) have been widely used in various industries related to electronics, ceramics, textiles, and nanomedicine. Ambient and occupational exposure to Ni-NPs may bring about potential detrimental effects on animals and humans. Thus, there is a growing effort to identify compounds that can ameliorate NPs-associated pathophysiologies. The present study examined Cinnamomum cassia (C. cassia) bark extracts (CMBE) for its ameliorative activity against Ni-NPs-induced pathophysiological and histopathological alterations in male Sprague Dawley rats. The biochemical analyses revealed that dosing rats with Ni-NPs at 10 mg/kg/body weight (b.w.) significantly altered the normal structural and biochemical adaptations in the liver and kidney. Conversely, supplementations with CMBE at different doses (225, 200, and 175 mg/kg/b.w. of rat) ameliorated the altered blood biochemistry and reduced the biomarkers of liver and kidney function considerably (p < 0.05) in a dose-dependent manner. However, the best results were at 225 mg/kg/b.w. of rat. The study provided preliminary information about the protective effect of C. cassia against Ni-NPs indicated liver and kidney damages. Future investigations are needed to explore C. cassia mechanism of action of C. cassia and isolation of single constituents of C. cassia to assess their pharmaceutical importance accordingly.

镍纳米颗粒（Ni-NPs）已广泛用于与电子，陶瓷，纺织品和纳米医学有关的各种行业。Ni-NPs的环境和职业暴露可能对动物和人类造成潜在的有害影响。因此，越来越多的努力来鉴定可以改善NPs相关病理生理的化合物。本研究检查了肉桂肉桂（C. cassia）树皮提取物（CMBE）对Ni-NPs诱导的雄性Sprague Dawley大鼠的病理生理和组织病理学改变具有改善作用。生化分析表明，以10 mg / kg /体重（bw）的Ni-NPs给药的大鼠显着改变了肝脏和肾脏的正常结构和生化适应性。相反，以不同剂量（225、200和175 mg / kg / bw的大鼠）补充CMBE可以改善血液生物化学的变化，并以剂量依赖性方式显着降低肝和肾功能的生物标志物（p <0.05）。但是，最好的结果是在225 mg / kg / bw的大鼠下。该研究提供了关于决明子的保护作用的初步信息。对抗Ni-NPs表示肝肾损害。还需要更多的研究来探索C.决明子的作用机制C.决明子和单一成分的分离C.决明子相应地评估其药物的重要性。