当前位置：
X-MOL 学术
›
Cryst. Growth Des.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Polymorphism and Particle Formation Pathway of Carbamazepine during Sonoprecipitation from Ionic Liquid Solutions
Crystal Growth & Design ( IF 3.2 ) Pub Date : 2020-06-23 , DOI: 10.1021/acs.cgd.0c00382 Rupanjali Prasad 1 , Kusum Panwar 1 , Jagadish Katla 2 , Sameer Vishvanath Dalvi 1
Crystal Growth & Design ( IF 3.2 ) Pub Date : 2020-06-23 , DOI: 10.1021/acs.cgd.0c00382 Rupanjali Prasad 1 , Kusum Panwar 1 , Jagadish Katla 2 , Sameer Vishvanath Dalvi 1
Affiliation
|
In this work, liquid antisolvent precipitation of carbamazepine (CBZ), an anticonvulsant and antiepileptic drug, was carried out from its solutions in an ionic liquid (IL), [BMIM][Cl], using water as an antisolvent. Precipitation was carried out in the presence of ultrasound and additives such as hydroxyl propyl methyl cellulose (HPMC), bovine serum albumin (BSA), and polyvinylpyrrolidone (PVP). In-situ Raman spectroscopy was employed to uncover any polymorphic transformations that might occur in the solution during precipitation. It was found that the dihydrate (DH) form of CBZ precipitated from IL solution irrespective of the additive or the mixing condition. However, characterization of the freeze-dried CBZ powders obtained from liquid antisolvent (LAS) precipitation revealed that the DH CBZ underwent dehydration and transformed selectively to anhydrous Form III (P-monoclinic) and Form I (triclinic) in the absence and presence of additives, respectively. The additives were found to influence the final polymorphic outcome by “kinetically entrapping” the metastable Form I during dehydration. The morphology of CBZ particles obtained under all conditions was found to be long needle-like where each individual needle appeared to have been formed by aggregation of several smaller needles. Time-resolved scanning electron microscopy studies show that the morphology of CBZ particles is a result of a non-classical particle formation pathway followed by secondary nucleation and growth.
中文翻译：
卡马西平在离子液体溶液声沉淀过程中的多态性和颗粒形成途径
在这项工作中，使用水作为抗溶剂，从其在离子液体（IL）[BMIM] [Cl]中的溶液中进行了卡马西平（CBZ）（一种抗惊厥药和抗癫痫药）的液体抗溶剂沉淀。在超声波和添加剂（例如羟丙基甲基纤维素（HPMC），牛血清白蛋白（BSA）和聚乙烯吡咯烷酮（PVP））的存在下进行沉淀。原位拉曼光谱法用于揭示沉淀过程中溶液中可能发生的任何多态转化。发现与添加剂或混合条件无关，CBZ的二水合物（DH）形式从IL溶液中沉淀出来。然而，对通过液体反溶剂（LAS）沉淀获得的冷冻干燥CBZ粉末的表征表明，DH CBZ进行了脱水并分别在不存在和存在添加剂的情况下分别转化为无水形式III（P-单斜晶）和形式I（三斜晶） 。发现这些添加剂通过在脱水过程中“动力学截留”亚稳态晶型I来影响最终的多晶型结果。发现在所有条件下获得的CBZ颗粒的形态为长针状，其中每个单独的针似乎是由几个较小的针的聚集形成的。时间分辨扫描电子显微镜研究表明，CBZ颗粒的形态是非经典的颗粒形成途径，继之以二次成核和生长的结果。
更新日期：2020-08-05
中文翻译：
卡马西平在离子液体溶液声沉淀过程中的多态性和颗粒形成途径
在这项工作中，使用水作为抗溶剂，从其在离子液体（IL）[BMIM] [Cl]中的溶液中进行了卡马西平（CBZ）（一种抗惊厥药和抗癫痫药）的液体抗溶剂沉淀。在超声波和添加剂（例如羟丙基甲基纤维素（HPMC），牛血清白蛋白（BSA）和聚乙烯吡咯烷酮（PVP））的存在下进行沉淀。原位拉曼光谱法用于揭示沉淀过程中溶液中可能发生的任何多态转化。发现与添加剂或混合条件无关，CBZ的二水合物（DH）形式从IL溶液中沉淀出来。然而，对通过液体反溶剂（LAS）沉淀获得的冷冻干燥CBZ粉末的表征表明，DH CBZ进行了脱水并分别在不存在和存在添加剂的情况下分别转化为无水形式III（P-单斜晶）和形式I（三斜晶） 。发现这些添加剂通过在脱水过程中“动力学截留”亚稳态晶型I来影响最终的多晶型结果。发现在所有条件下获得的CBZ颗粒的形态为长针状，其中每个单独的针似乎是由几个较小的针的聚集形成的。时间分辨扫描电子显微镜研究表明，CBZ颗粒的形态是非经典的颗粒形成途径，继之以二次成核和生长的结果。
京公网安备 11010802027423号