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Nanotechnology for COVID-19: Therapeutics and Vaccine Research.
ACS Nano ( IF 15.8 ) Pub Date : 2020-06-22 , DOI: 10.1021/acsnano.0c04006 Gaurav Chauhan 1 , Marc J Madou 1, 2 , Sourav Kalra 3 , Vianni Chopra 4 , Deepa Ghosh 4 , Sergio O Martinez-Chapa 1
ACS Nano ( IF 15.8 ) Pub Date : 2020-06-22 , DOI: 10.1021/acsnano.0c04006 Gaurav Chauhan 1 , Marc J Madou 1, 2 , Sourav Kalra 3 , Vianni Chopra 4 , Deepa Ghosh 4 , Sergio O Martinez-Chapa 1
Affiliation
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The current global health threat by the novel coronavirus disease 2019 (COVID-19) requires an urgent deployment of advanced therapeutic options available. The role of nanotechnology is highly relevant to counter this “virus” nano enemy. Nano intervention is discussed in terms of designing effective nanocarriers to counter the conventional limitations of antiviral and biological therapeutics. This strategy directs the safe and effective delivery of available therapeutic options using engineered nanocarriers, blocking the initial interactions of viral spike glycoprotein with host cell surface receptors, and disruption of virion construction. Controlling and eliminating the spread and reoccurrence of this pandemic demands a safe and effective vaccine strategy. Nanocarriers have potential to design risk-free and effective immunization strategies for severe acute respiratory syndrome coronavirus 2 vaccine candidates such as protein constructs and nucleic acids. We discuss recent as well as ongoing nanotechnology-based therapeutic and prophylactic strategies to fight against this pandemic, outlining the key areas for nanoscientists to step in.
中文翻译：
COVID-19 纳米技术：治疗和疫苗研究。
当前 2019 年新型冠状病毒病 (COVID-19) 对全球健康构成的威胁需要紧急部署先进的治疗方案。纳米技术的作用与对抗这种“病毒”纳米敌人密切相关。纳米干预的讨论是通过设计有效的纳米载体来克服抗病毒和生物治疗的传统局限性。该策略指导使用工程纳米载体安全有效地提供可用的治疗方案，阻断病毒刺突糖蛋白与宿主细胞表面受体的初始相互作用，并破坏病毒颗粒的构建。控制和消除这一流行病的传播和复发需要安全有效的疫苗策略。纳米载体有潜力为严重急性呼吸综合征冠状病毒2候选疫苗（例如蛋白质构建体和核酸）设计无风险且有效的免疫策略。我们讨论了最近以及正在进行的基于纳米技术的治疗和预防策略来对抗这一流行病，概述了纳米科学家介入的关键领域。
更新日期：2020-07-28
中文翻译：
COVID-19 纳米技术：治疗和疫苗研究。
当前 2019 年新型冠状病毒病 (COVID-19) 对全球健康构成的威胁需要紧急部署先进的治疗方案。纳米技术的作用与对抗这种“病毒”纳米敌人密切相关。纳米干预的讨论是通过设计有效的纳米载体来克服抗病毒和生物治疗的传统局限性。该策略指导使用工程纳米载体安全有效地提供可用的治疗方案，阻断病毒刺突糖蛋白与宿主细胞表面受体的初始相互作用，并破坏病毒颗粒的构建。控制和消除这一流行病的传播和复发需要安全有效的疫苗策略。纳米载体有潜力为严重急性呼吸综合征冠状病毒2候选疫苗（例如蛋白质构建体和核酸）设计无风险且有效的免疫策略。我们讨论了最近以及正在进行的基于纳米技术的治疗和预防策略来对抗这一流行病，概述了纳米科学家介入的关键领域。
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