Abstract

Reproducible and reliable scientific investigation depends on the identification and consideration of various intrinsic and extrinsic factors that may affect the model system used. The impact of these factors must be managed during all phases of a study: planning, execution, and reporting. The value of in vivo (animal) research has come under increasing scrutiny over the past decade because of multiple reports documenting poor translatability to human studies. These failures have been attributed to various causes, including poor study design and execution as well as deficiencies in reporting. It is important to recognize that achieving reproducible and reliable preclinical research results is a joint responsibility that requires a partnership between the investigative team and the animal care and use program staff. The myriad of intrinsic factors, such as species, strain/substrain, age, sex, physiologic and health status, and extrinsic factors, including temperature, humidity, lighting, housing system, and diet, need to be recognized and managed during study planning and execution, as they can influence animal physiology and biological response. Of equal importance is the need to document and report these details. The ARRIVE and PREPARE guidelines were developed by concerned scientists, veterinarians, statisticians, journal editors, and funding agencies to assist investigative teams and scientific journals manage and report on intrinsic and extrinsic factors to improve reproducibility and reliability. This issue of the ILAR Journal will focus on the various extrinsic factors that have been recognized to confound animal research.

中文翻译：

---

在临床前研究中提高可重复性，可重复性和可靠性：共同的责任

摘要

可再现和可靠的科学研究取决于对可能影响所使用模型系统的各种内在和外在因素的识别和考虑。这些因素的影响必须在研究的所有阶段中进行管理：计划，执行和报告。在过去的十年中，由于许多报道表明对人体研究的可翻译性较差，因此体内（动物）研究的价值受到了越来越多的审查。这些失败归因于各种原因，包括研究设计和执行不佳以及报告不足。重要的是要认识到，获得可重复和可靠的临床前研究结果是一项共同责任，需要研究团队与动物护理和使用计划人员之间建立合作关系。无数种内在因素，如物种，品系/亚种​​，年龄，性别，生理和健康状况，以及外部因素（包括温度，湿度，光照，住房系统和饮食），需要在研究计划和执行过程中加以识别和管理，因为它们会影响动物生理和生物学反应。同样重要的是需要记录和报告这些细节。有关的科学家，兽医，统计学家，期刊编辑和资助机构制定了ARRIVE和PREPARE指南，以协助调查团队和科学期刊管理和报告内在和外在因素，以提高可重复性和可靠性。本期 在研究计划和执行过程中需要得到认可和管理，因为它们会影响动物的生理和生物学反应。同样重要的是需要记录和报告这些细节。有关的科学家，兽医，统计学家，期刊编辑和资助机构制定了ARRIVE和PREPARE指南，以协助调查团队和科学期刊管理和报告内在和外在因素，以提高可重复性和可靠性。本期 在研究计划和执行过程中需要得到认可和管理，因为它们会影响动物的生理和生物学反应。同样重要的是需要记录和报告这些细节。有关的科学家，兽医，统计学家，期刊编辑和资助机构制定了ARRIVE和PREPARE指南，以协助调查团队和科学期刊管理和报告内在和外在因素，以提高可重复性和可靠性。本期 以及资助机构，以协助调查团队和科学期刊管理和报告内在和外在因素，以提高可重复性和可靠性。本期 以及资助机构，以协助调查团队和科学期刊管理和报告内在和外在因素，以提高可重复性和可靠性。本期《 ILAR杂志》将关注那些已经被混淆了动物研究的各种外在因素。