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Jack of all trades inhibits inflammation (in sober people).
Nature Immunology ( IF 27.7 ) Pub Date : 2020-06-23 , DOI: 10.1038/s41590-020-0693-6
Florian I Schmidt 1 , Eicke Latz 1, 2, 3
Affiliation  

Caspase-cleaved gasdermin D forms pores in cellular membranes, thus executing proinflammatory cell death by pyroptosis. Disulfiram — a drug used to treat chronic alcoholism — is now found to be an inhibitor of pore formation, which may therapeutically counteract exacerbated inflammation in sepsis and beyond.

中文翻译:

各行各业的杰克(在清醒的人中)抑制炎症。

半胱天冬酶切割的胃泌素D在细胞膜上形成孔,从而通过焦磷酸化而导致促炎性细胞死亡。现已发现双硫仑(一种用于治疗慢性酒精中毒的药物)是毛孔形成的抑制剂,可以治疗性地抵消脓毒症及其他疾病中加剧的炎症。
更新日期:2020-06-23
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