Caspase-cleaved gasdermin D forms pores in cellular membranes, thus executing proinflammatory cell death by pyroptosis. Disulfiram — a drug used to treat chronic alcoholism — is now found to be an inhibitor of pore formation, which may therapeutically counteract exacerbated inflammation in sepsis and beyond.

中文翻译：

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各行各业的杰克（在清醒的人中）抑制炎症。

半胱天冬酶切割的胃泌素D在细胞膜上形成孔，从而通过焦磷酸化而导致促炎性细胞死亡。现已发现双硫仑（一种用于治疗慢性酒精中毒的药物）是毛孔形成的抑制剂，可以治疗性地抵消脓毒症及其他疾病中加剧的炎症。