Polyethylenimine-Assisted Generation of Optical Nanoprobes for Biosensing Applications,ACS Applied Bio Materials

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Polyethylenimine-Assisted Generation of Optical Nanoprobes for Biosensing Applications
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-06-23 , DOI: 10.1021/acsabm.0c00536
Jingchao Li ₁ , Xiaoying Wang ₂ , Mingwu Shen ₁ , Xiangyang Shi _{1,

3}

Affiliation

Detection of analytes in biological systems is pivotal to explore their physiological roles and provide diagnostic and treatment options for related diseases, which however remains a great challenge. Optical nanoprobes that exhibit absorption or fluorescence signal changes in response to the targets of interest have emerged as a versatile class of biosensors in the field. Polyethylenimine (PEI) with abundant amine groups plays indispensable roles in the construction of optical nanoprobes and mediating the sensing processes. After interaction with analytes, PEI-based optical nanoprobes can be induced to form aggregates, be disassembled or separated into individual units, or undergo structure/component alterations. As such, the optical properties of these nanoprobes have corresponding changes, allowing for sensitive and selective detection of a wide variety of analytes in biological environment. Up to now, detections of reactive oxygen species, pH, metal ions, biothiols, neurotransmitters, therapeutic agents, oxygen levels, enzyme activities, and virus/bacteria have been successfully demonstrated using PEI-based optical nanoprobes. Herein, we summarize the recent developments of PEI-based optical nanoprobes for biosensing applications and highlight the probe designs and sensing mechanisms. The existing challenges and prospects regarding biosensing applications of PEI-based optical nanoprobes are also briefly discussed.

中文翻译：

聚乙烯亚胺辅助生成用于生物传感应用的光学纳米探针

允许对生物环境中的多种分析物进行灵敏和选择性检测。到目前为止，使用基于 PEI 的光学纳米探针已经成功地证明了对活性氧、pH、金属离子、生物硫醇、神经递质、治疗剂、氧水平、酶活性和病毒/细菌的检测。在此，我们总结了基于 PEI 的光学纳米探针在生物传感应用中的最新进展，并重点介绍了探针设计和传感机制。还简要讨论了基于 PEI 的光学纳米探针的生物传感应用的现有挑战和前景。已经使用基于 PEI 的光学纳米探针成功地证明了病毒/细菌。在此，我们总结了基于 PEI 的光学纳米探针在生物传感应用中的最新进展，并重点介绍了探针设计和传感机制。还简要讨论了基于 PEI 的光学纳米探针的生物传感应用的现有挑战和前景。已经使用基于 PEI 的光学纳米探针成功地证明了病毒/细菌。在此，我们总结了基于 PEI 的光学纳米探针在生物传感应用中的最新进展，并重点介绍了探针设计和传感机制。还简要讨论了基于 PEI 的光学纳米探针的生物传感应用的现有挑战和前景。

更新日期：2020-07-20

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