Epidemiology and clinical course of COVID-19 in Shanghai, China.,Emerging Microbes & Infections

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Epidemiology and clinical course of COVID-19 in Shanghai, China.
Emerging Microbes & Infections ( IF 8.4 ) Pub Date : 2020-07-07 , DOI: 10.1080/22221751.2020.1787103
Yinzhong Shen ₁ , Fang Zheng ₂ , Danfeng Sun ₂ , Yun Ling ₃ , Jun Chen ₁ , Feng Li ₄ , Tao Li ₅ , Zhiping Qian ₆ , Yuyi Zhang ₆ , Qingnian Xu ₇ , Li Liu ₁ , Qin Huang ₃ , Fei Shan ₈ , Lie Xu ₂ , Jun Wu ₂ , Zhaoqin Zhu ₉ , Zhigang Song ₁₀ , Shenyang Li ₁₁ , Yuxin Shi ₈ , Jianliang Zhang ₁₂ , Xueyun Wu ₁ , Joshua B Mendelsohn ₁₃ , Tongyu Zhu ₁₄ , Hongzhou Lu ₁

Affiliation

Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
Department of Medical Affairs, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
Department of Infection, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
Department of Respiratory Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
Department of Tuberculosis, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
Department of Severe Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Department of Traditional Chinese Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
Clinical Laboratory, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
P3 Laboratory, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
Data Management Center, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
Department of Gastroenterology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
College of Health Professions, Pace University, New York, NY, USA.
Department of Urology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.

ABSTRACT

Background: Novel coronavirus pneumonia (COVID-19) is prevalent around the world. We aimed to describe epidemiological features and clinical course in Shanghai.

Methods: We retrospectively analysed 325 cases admitted at Shanghai Public Health Clinical Center, between January 20 and February 29, 2020.

Results: 47.4% (154/325) had visited Wuhan within 2 weeks of illness onset. 57.2% occurred in 67 clusters; 40% were situated within 53 family clusters. 83.7% developed fever during the disease course. Median times from onset to first medical care, hospitalization and negative detection of nucleic acid by nasopharyngeal swab were 1, 4 and 8 days. Patients with mild disease using glucocorticoid tended to have longer viral shedding in blood and feces. At admission, 69.8% presented with lymphopenia and 38.8% had elevated D-dimers. Pneumonia was identified in 97.5% (314/322) of cases by chest CT scan. Severe-critical patients were 8% with a median time from onset to critical disease of 10.5 days. Half required oxygen therapy and 7.1% high-flow nasal oxygen. The case fatality rate was 0.92% with median time from onset to death of 16 days.

Conclusion: COVID-19 cases in Shanghai were imported. Rapid identification, and effective control measures helped to contain the outbreak and prevent community transmission.

更新日期：2020-07-07

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