Abstract

Thiourea and its derivatives are versatile compounds used in several fields of life ranging from medicinal to chemosensor applications. In this review article, generally used preparative methods of thiourea, its coordination compounds with selected metals (Cu, Ag, Au) for biological and medicinal applications and the potentials of thiourea derivatives in analytical chemistry as chemosensors have been discussed. The improved activities of these derivatives in the field of pharmaceutical chemistry can be achieved by coordination with a suitable metal ion. The two fields, selected coordination chemistry and chemosensing of thiourea derivatives are discussed. Since thiourea derivatives are biologically active therefore, their use as chemosensors can be useful to detect anions and cations in environmental and biological samples. The review contains 212 references.

摘要

硫脲及其衍生物是用途广泛的化合物，可用于从医药到化学传感器应用的多个生活领域。在这篇综述文章中，讨论了硫脲的常用制备方法、其与选定金属（Cu、Ag、Au）的配位化合物用于生物和医学应用，以及硫脲衍生物在分析化学中作为化学传感器的潜力。这些衍生物在药物化学领域的活性提高可以通过与合适的金属离子配位来实现。讨论了硫脲衍生物的选择性配位化学和化学传感两个领域。由于硫脲衍生物具有生物活性，因此它们用作化学传感器可用于检测环境和生物样品中的阴离子和阳离子。