Progesterone is in constant fluctuation throughout the lifespan of the horse. As a key regulator of the hypothalamic–pituitary–gonadal axis, progesterone is involved in numerous aspects of reproduction. Synthetic analogs of progesterone, deemed progestins, are widely available to industry to act as progestogenic within the reproductive tract, although few are bioactive in the horse. Utilised to suppress oestrous, delay ovulation, maintain pregnancy, and for behavioural modifications, progestins are a commonly administered class of pharmaceuticals in veterinary medicine. In this review, we discuss the progestins available to equine industry, in addition to assessing efficacy, pharmacokinetics, and potential side effects following administration of each.

中文翻译：

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孕激素在马药中的应用：综述

黄体酮在马的整个生命周期中都在不断波动。作为下丘脑-垂体-性腺轴的关键调节剂，孕酮参与生殖的许多方面。孕酮的合成类似物，被认为是孕激素，可广泛用于工业，在生殖道内充当孕激素，尽管很少有马具有生物活性。用于抑制发情、延迟排卵、维持妊娠和改变行为，孕激素是兽医学中常用的一类药物。在这篇综述中，我们讨论了马业可用的孕激素，此外还评估了每种孕激素的疗效、药代动力学和潜在副作用。