Abstract Hydrophilic lubricious coatings on the catheter surface reduce friction against the blood vessel wall but give rise to iatrogenic complication of particle release, embolization and thin blood vessel blockage leading to pulmonary infarction and stroke. Layer by layer deposited PLL (poly- l -lysine) and HA (hyaluronan) coating fills the urgent need of thinner lubricious coating which does not lead to release of large particles. The 8 layered PLL-HA coating was able to maintain low friction and prevent wear of endothelial glycocalyx layer (EGL). Wear and loss of EGL is a gradual process and occurred while sliding the blood vessel against bare catheter surface or 4 layered coating accompanied by epithelial cells damage and decrease in the number of nucleuses.

中文翻译：

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一种用于心血管导管的透明质酸基润滑涂层

摘要 导管表面的亲水性润滑涂层减少了与血管壁的摩擦，但会引起颗粒释放、栓塞和细血管阻塞等医源性并发症，导致肺梗塞和中风。逐层沉积的 PLL（聚赖氨酸）和 HA（透明质酸）涂层满足了对不会导致大颗粒释放的更薄润滑涂层的迫切需求。8 层 PLL-HA 涂层能够保持低摩擦并防止内皮糖萼层 (EGL) 磨损。EGL 的磨损和丢失是一个渐进的过程，发生在血管在裸露的导管表面或 4 层涂层上滑动时，伴随上皮细胞损伤和细胞核数量减少。