Bacteria as a foreign pathogen can alter the physiology and metabolism of the host. Many of the teeth infecting bacteria known to be associated with obesity and diabetes in various organisms. The current study aims to check the effect of teeth infecting bacteria Enterobacter ludwigii on model organism Drosophila melanogaster. To check the effect, various concentrations of E. ludwigii on fly physiology the bacteria were added to the fly food. Flies were allowed to grow and colonise in infected food. The offsprings were checked for the accumulation of lipid and fat. With the increase of bacteria within the gut the amount of lipid and fat increases. Alongwith the fat various biochemical parameters like glucose, trehalose, protein and triglyceride level found to be altered. Within the fly gut various metals, which have a role in the metabolism is altered. However, during colonisation within the gut, the morphology of the bacteria remains unaltered. In the adult fly, all the biochemical parameters like glucose, trehalose, protein and triglyceride level increased. The expression level of Dilp is upregulated. Altogether, the current study reports an infection of E. ludwigii causes the accumulation of fat and alters glucose metabolism in Drosophila melanogaster.

细菌作为外来病原体可以改变宿主的生理和代谢。已知许多牙齿感染细菌与各种生物体中的肥胖症和糖尿病有关。目前的研究目的是检验牙齿感染细菌路德维希肠杆菌对黑腹果蝇（Drosophila melanogaster）的影响。为了检查效果，各种浓度的路德维希E.在果蝇生理上，细菌被添加到果蝇食品中。允许蝇类在受感染的食物中生长和定殖。检查后代中脂质和脂肪的积累。随着肠道内细菌的增加，脂质和脂肪的数量也会增加。与脂肪一起，发现各种生物化学参数（例如葡萄糖，海藻糖，蛋白质和甘油三酯水平）也发生了变化。在飞肠中，在代谢中起作用的各种金属被改变了。但是，在肠道内定植期间，细菌的形态保持不变。在成年蝇中，所有生化参数如葡萄糖，海藻糖，蛋白质和甘油三酸酯水平都增加了。Dilp的表达水平上调。总而言之，当前的研究报道了路德维希大肠杆菌的感染引起果蝇体内脂肪积累和葡萄糖代谢改变。