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CD8+CD122+ T cell homeostasis is controlled by different levels of IL-15 trans-presentation
Journal of Microbiology, Immunology and Infection ( IF 4.5 ) Pub Date : 2020-06-23 , DOI: 10.1016/j.jmii.2020.06.005 Gilbert Aaron Lee, Nan-Shih Liao
中文翻译:
CD8+CD122+ T 细胞稳态受不同水平的 IL-15 反式呈递控制
更新日期:2020-06-23
Journal of Microbiology, Immunology and Infection ( IF 4.5 ) Pub Date : 2020-06-23 , DOI: 10.1016/j.jmii.2020.06.005 Gilbert Aaron Lee, Nan-Shih Liao
The homeostasis of CD8+CD122+ T cell requires IL-15 trans-presentation. We use Il15ra mutant mice and bone marrow chimeras to assess the role of IL-15 trans-presentation level in CD8+CD122+ T cells homeostasis. We demonstrate that CD8+CD122+ T cells require different levels of IL-15 trans-presentation to support their homeostasis.
中文翻译:
CD8+CD122+ T 细胞稳态受不同水平的 IL-15 反式呈递控制
CD8 + CD122 + T 细胞的稳态需要 IL-15 反式呈递。我们使用Il15ra突变小鼠和骨髓嵌合体来评估 IL-15 反式呈递水平在 CD8 + CD122 + T 细胞稳态中的作用。我们证明 CD8 + CD122 + T 细胞需要不同水平的 IL-15 反式呈递来支持其体内平衡。