Despite the progress in the development of hemostatic products, efficient treatment solutions to control hemorrhage upon wounding are still necessary. Chitosan (CS) is a natural hydrogel-forming polysaccharide, easy to modify for specific applications. Inorganic compounds in turn possess documented hemostatic properties. In this study, innovative hemostatic products based on CS, containing the inorganic additives aluminum chloride, aluminum sulfate hydrate or iron(III) sulfate and the antibiotic Levofloxacin were prepared, and their potential use as hemostatic materials was investigated. Structural characteristics, physical state and drug loading/release properties were examined. Strong interactions developed between CS and the additives, the pore size in the resulting products was affected, swelling increased up to 2500% and the stability of the wound dressings improved. The crystallinity of Levofloxacin reduced, and its release was immediate. The materials showed biocompatibility upon contact with cultured keratinocytes, hemocompatibility and hemostatic efficacy in vitro and in vivo.

尽管止血产品的开发取得了进展，但是仍然需要有效的治疗方案来控制伤口受伤时的出血。壳聚糖（CS）是天然的形成水凝胶的多糖，易于针对特定应用进行修饰。无机化合物又具有记录的止血特性。本研究制备了基于CS的创新止血产品，其中包含无机添加剂氯化铝，水合硫酸铝或硫酸铁（III）和抗生素左氧氟沙星，并研究了它们作为止血材料的潜在用途。检查了结构特征，物理状态和药物负载/释放特性。CS和添加剂之间形成了很强的相互作用，影响了最终产品的孔径，溶胀增加至2500％，伤口敷料的稳定性得到改善。左氧氟沙星的结晶度降低，并且立即释放。该材料与培养的角质形成细胞接触后显示出生物相容性，血液相容性和止血功效体外和体内。