The development, validation, and appropriate application of serological assays to detect antibodies to SARS-CoV-2 are essential to determining seroprevalence of this virus in the United States and globally and in guiding government leadership and the private sector on back-to-work policies. An interagency working group of the US Department of Health and Human Services convened a virtual workshop to identify knowledge gaps and key outstanding scientific issues and to develop strategies to fill them. Key outcomes of the workshop included recommendations for (1) advancing serology assays as a tool to better understand SARS-CoV-2 infection and (2) conducting crucial serology field studies to advance an understanding of immunity to SARS-CoV-2, leading to protection and duration of protection, including the correlation between serological test results and risk of reinfection.

开发、验证和适当应用血清学检测方法来检测 SARS-CoV-2 抗体对于确定该病毒在美国和全球的血清流行情况以及指导政府领导层和私营部门制定返岗政策至关重要。美国卫生与公众服务部的一个跨机构工作组召开了一次虚拟研讨会，以确定知识差距和关键的突出科学问题，并制定填补这些问题的战略。研讨会的主要成果包括以下建议：(1) 推进血清学检测作为更好地了解 SARS-CoV-2 感染的工具，以及 (2) 进行重要的血清学现场研究，以增进对 SARS-CoV-2 免疫力的了解，从而保护和保护持续时间，包括血清学检测结果与再感染风险之间的相关性。