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β-Lactams as promising anticancer agents: Molecular hybrids, structure activity relationships and potential targets.
European Journal of Medicinal Chemistry ( IF 6.0 ) Pub Date : 2020-06-23 , DOI: 10.1016/j.ejmech.2020.112510
Dong-Jun Fu 1 , Yun-Feng Zhang 1 , An-Qi Chang 1 , Jun Li 1
Affiliation  

β-Lactam, commonly referred as azetidin-2-one, is a multifunctional building block for synthesizing β-amino ketones, γ-amino alcohols, and other compounds. Besides its well known antibiotic activity, this ring system exhibits a wide range of activities, attracting the attention of researchers. However, the structurally diverse β-lactam analogues as anticancer agents and their different molecular targets are poorly discussed. The purpose of this review is 3-fold: (1) to explore the molecular hybridization approach to design β-lactams hybrids as anticancer agents; (2) the structure activity relationship of the most active anticancer β-lactams and (3) to summarize their antitumor mechanisms.



中文翻译:

β-内酰胺作为有希望的抗癌药:分子杂种,结构活性关系和潜在靶标。

β-内酰胺,通常称为azetidin-2-one,是用于合成β-氨基酮,γ-氨基醇和其他化合物的多功能构件。除了其众所周知的抗生素活性外,该环系统还具有广泛的活性,吸引了研究人员的注意。然而,关于结构多样的β-内酰胺类似物作为抗癌剂及其分子靶标的讨论很少。这篇综述的目的是三方面的:(1)探索分子杂交方法来设计β-内酰胺类杂种作为抗癌剂;(2)最活跃的抗癌β-内酰胺的结构活性关系和(3)总结其抗肿瘤机制。

更新日期:2020-06-25
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