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Anaesthesia-dependent oscillatory EEG features in the super-elderly
Clinical Neurophysiology ( IF 3.7 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.clinph.2020.05.027
K Hayashi 1 , K Indo 2 , T Sawa 3
Affiliation  

OBJECTIVE Although the characteristics of electroencephalograms (EEGs) have been reported to change with age, anaesthesia-dependent oscillatory features and reactivity of the super-elderly EEG to anaesthesia have not been examined in detail. METHODS Participants comprised 20 super-elderly patients (age; mean ± standard deviation, 87.1 ± 3.8 years) and 20 young adult patients (35.5 ± 8.5 years). At three levels of sevoflurane anaesthesia (minimum alveolar concentration [MAC] of 0.3, 0.7, and 1.4), oscillatory features of the frontal EEG were examined by analysing quadratic phase coupling (bicoherence) and power spectrum in α and δ-θ areas and compared in an anaesthesia-dependent manner, using the Friedman test. RESULTS Among super-elderly individuals, bicoherences in the δ-θ area showed anaesthesia-dependent increases (median [interquartile range], 12.9% [5.2%], 19.2% [9.1%], 23.3% [8.7%]; 0.3, 0.7, 1.4 MAC sevoflurane, p = 0.000), whereas bicoherence in the α area did not change at these different anaesthesia levels (11.2% [3.9%], 12.5% [4.4%], 14.1% [5.7%], respectively; p = 0.142), counter to the results found in young adult patients, where both δ-θ and α bicoherences changed with anaesthesia. CONCLUSIONS In the super-elderly, δ-θ bicoherence of EEG shows anaesthesia- dependent changes, whereas α activity remains small irrespective of anaesthesia level. SIGNIFICANCE Quantification of δ-θ bicoherence is a candidate for anaesthesia monitoring in the super-elderly.

中文翻译:

超长者的麻醉依赖性振荡脑电图特征

目的 尽管据报道脑电图 (EEG) 的特征会随着年龄的增长而改变,但尚未详细研究麻醉依赖性振荡特征和高龄脑电图对麻醉的反应性。方法 参与者包括 20 名高龄患者(年龄;平均值 ± 标准差,87.1 ± 3.8 岁)和 20 名年轻成人患者(35.5 ± 8.5 岁)。在三个水平的七氟醚麻醉下(最低肺泡浓度 [MAC] 为 0.3、0.7 和 1.4),通过分析 α 和 δ-θ 区域的二次相位耦合(双相干)和功率谱来检查额叶 EEG 的振荡特征并进行比较以依赖麻醉的方式,使用弗里德曼检验。结果 在高龄个体中,δ-θ 区域的双相干显示麻醉依赖性增加(中位数 [四分位距],12.9%【5.2%】、19.2%【9.1%】、23.3%【8.7%】;0.3、0.7、1.4 MAC 七氟醚,p = 0.000),而在这些不同的麻醉水平下,α 区域的双相干性没有变化(分别为 11.2% [3.9%]、12.5% [4.4%]、14.1% [5.7%]) ; p = 0.142),这与在年轻成人患者中发现的结果相反,其中 δ-θ 和 α 双相干性都随着麻醉而改变。结论在超老年人中,脑电图的δ-θ双相干显示麻醉依赖性变化,而不管麻醉水平如何,α活性仍然很小。意义 δ-θ 双相干性的量化是高龄麻醉监测的候选者。p = 0.142),这与在年轻成人患者中发现的结果相反,其中 δ-θ 和 α 双相干性都随着麻醉而改变。结论在超老年人中,脑电图的δ-θ双相干显示麻醉依赖性变化,而无论麻醉水平如何,α活性仍然很小。意义 δ-θ 双相干性的量化是高龄麻醉监测的候选者。p = 0.142),这与在年轻成人患者中发现的结果相反,其中 δ-θ 和 α 双相干性都随着麻醉而改变。结论在超老年人中,脑电图的δ-θ双相干显示麻醉依赖性变化,而不管麻醉水平如何,α活性仍然很小。意义 δ-θ 双相干性的量化是高龄麻醉监测的候选者。
更新日期:2020-09-01
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